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STAT 416: Statistical Design and Analysis of Gene Expression Experiments

(3-0) Cr. 3. S.

Prereq: STAT 301 or STAT 326 or STAT 401
Introduction to high-throughput technologies for gene expression studies (especially RNA-sequencing technology): the role of blocking, randomization, and biological and technical replication in the design of gene expression experiments; normalization methods; methods for identifying differentially expressed genes including mixed linear model analysis, generalized linear model analysis, generalized linear mixed model analysis, quasi-likelihood methods, empirical Bayes analysis, and resampling based approaches; procedures for controlling false discovery rate for multiple testing; clustering and classification problems for gene expression data; testing gene categories; emphasis on practical use of methods.