Interdepartmental Graduate Major
Toxicology is the science of studying the adverse effects of substances on living organisms. Students observe, gather data and predict risks and outcomes in populations. Whole organism research and cellular and molecular approaches are used to determine toxicant exposure and mechanisms. Work is offered for the degrees doctor of philosophy and master of science. Students majoring in toxicology will be affiliated with one of the following cooperating departments: Agricultural and Biosystems Engineering; Animal Science; Biochemistry, Biophysics and Molecular Biology; Biomedical Sciences; Chemistry; Entomology; Food Science and Human Nutrition; Genetics, Development and Cell Biology; Geological and Atmospheric Sciences; Natural Resource Ecology and Management; Physics; Plant Pathology and Microbiology; Veterinary Diagnostic and Production Animal Medicine; Veterinary Microbiology and Preventive Medicine; and Veterinary Pathology.
The prerequisites for entrance into the graduate toxicology major include an undergraduate degree in a relevant area of study; for example, chemical engineering, biology, biochemistry, chemistry, ecology, entomology, food science and technology, microbiology, nutritional science, zoology, or veterinary medicine. Minimum undergraduate coursework should include the following or their equivalent:
- 1 year of college mathematics, including calculus
- 1 year of inorganic chemistry with quantitative analysis
- 1 course in physics
- 1 year of organic chemistry
- 2 years of biological sciences including 1 course in physiology
Other courses that are considered desirable in undergraduate preparation include: biochemistry, physical chemistry, qualitative analysis, and some specialized courses such as histology or advanced physiology.
Facilities and faculty are available for fundamental research in such areas as agricultural toxicology, drug discovery and prevention, ecotoxicology, environmental fate and effects of chemicals, insect toxicology, aquatic toxicology, food safety, nutritional toxicology, mycotoxins, neurotoxicology, cellular and molecular toxicology, reproductive toxicology, and veterinary toxicology.
Ph.D. and M.S. Students should register for TOX 689 (R) every fall and spring semester during their training.
Students majoring in toxicology will be affiliated with a cooperating department. All Ph.D. students take a core curriculum consisting of:
| TOX 501 | Principles of Toxicology | 3 |
| TOX 502 | Toxicology Methods | 3 |
| TOX 504 | Toxicology Seminar (taken twice) | 1 |
| 7 additional credits in approved toxicology courses | 7 | |
| Biochemistry II (2 additional credits of biochemistry courses) | ||
| Biochemistry I | ||
| 2 additional credits of upper level BBMB coursework. 3 credits in physiology, histology, pathology, neuroscience, immunobiology or cellular and molecular biology. | 2 and 3 | |
| STAT 402 | Statistical Design and the Analysis of Experiments | 3 |
| STAT 587 | Statistical Methods for Research Workers | 4 |
| GR ST 565 | Responsible Conduct of Research in Science and Engineering (or) | 1 |
| V PTH 554 | Ethics in Scientific Research and Writing | 1 |
M.S. students take a core of:
| TOX 501 | Principles of Toxicology | 3 |
| TOX 502 | Toxicology Methods | 3 |
| TOX 504 | Toxicology Seminar | 1 |
| 3 additional credits in approved toxicology courses | 3 | |
| BBMB 404 | Biochemistry I | 3 |
| BBMB 405 | Biochemistry II | 3 |
| STAT 587 | Statistical Methods for Research Workers | 4 |
| Additional coursework is selected to meet departmental requirements and to satisfy individual student research interests | ||
| GR ST 565 | Responsible Conduct of Research in Science and Engineering (or) | 1 |
| V PTH 554 | Ethics in Scientific Research and Writing | 1 |
A graduate minor in toxicology is available for students enrolled in other majors.
A minor for an M.S. degree includes one semester of TOX 689X and:
| TOX 504 | Toxicology Seminar | 1 |
| TOX 501 | Principles of Toxicology | 3 |
| 3 credits in other approved toxicology courses | 3 | |
A minor at the Ph.D. level includes one semester of TOX 689X and:
| TOX 504 | Toxicology Seminar | 1 |
| TOX 501 | Principles of Toxicology | 3 |
| 6 credits in other approved toxicology course work | 6 | |
One member of the student’s program of study committee will be a member of the toxicology faculty.
Most students awarded doctoral degrees continue their training as postdoctoral associates at major research institutions in the U.S. or abroad in preparation for research and/or teaching positions in academia, industry, the military, veterinary research, or government environmental and public health institutions. A few go directly to permanent research positions in industry. Many students awarded master’s degrees continue their training as doctoral students; however, some choose research support positions (i.e., technician, chemist, research associate) in academia, industry, or government. A more thorough list of outcomes is available at our Web site.
Graduates of the Toxicology major will be able to carefully design, execute and analyze experiments that extend the knowledge of toxicology and closely related sciences. They will be able to clearly communicate research findings, and thoroughly evaluate the literature of toxicology, contributing significantly to the advancement of the field.
Courses
Courses primarily for undergraduates:
(Dual-listed with TOX 501). (3-0) Cr. 3. F.
Prereq: BBMB 404 or equivalent
Principles of toxicology governing entry, fate, and effects of toxicants on living systems. Includes toxicokinetics and foreign compound metabolism relative to toxification or detoxification. Fundamentals of foreign compound effects on metabolism, physiology, and morphology of different cell types, tissues, and organ systems.
(Cross-listed with FS HN, MICRO). (3-0) Cr. 3. Alt. S., offered even-numbered years.
Prereq: MICRO 201 or MICRO 302, a course in biochemistry
Pathogenesis of human microbiological foodborne infections and intoxications, principles of toxicology, major classes of toxicants in the food supply, governmental regulation of foodborne hazards. Assessed service learning component.
Only one of FS HN 419 and FS HN 519 may count toward graduation.
(Dual-listed with TOX 526). (Cross-listed with VDPAM). (3-0) Cr. 3. S.
Prereq: Third year classification in veterinary medicine
Study of toxicological diseases of animals emphasizing clinical recognition, circumstances of poisoning, differential diagnosis with clinical and laboratory data, therapeutic procedures, preventive management and public health implications. Supplemented with case-based materials.
(Dual-listed with TOX 529). (2-0) Cr. 2. Alt. F., offered odd-numbered years.
Prereq: A course in biochemistry
Mechanisms of action, metabolism, sources, remediation or detoxification, risk assessment of major foodborne toxicants of current interest, design of HACCP plans for use in food industries targeting foodborne toxicants. Taught online only.
Cr. 1-2. Repeatable. F.S.SS.
Prereq: Permission of instructor is required prior to registration.
Independent study with a faculty mentor. Intended for students enrolled in the Pharmacology and Toxicology minor.
Students in the Pharmacology and Toxicology minor may use no more than 9 credits of university-wide 490 credits towards the total of 120 credits required for graduation.
Cr. 1-3. Repeatable, maximum of 3 credits. F.S.SS.
Prereq: Permission of instructor is required prior to registration.
Independent research under faculty guidance. Intended for students enrolled in the Pharmacology and Toxicology minor.
Offered on a satisfactory-fail basis only. Students may use no more than 9 credits of university-wide 499 credits towards the total of 120 credits required for graduation.
Courses primarily for graduate students, open to qualified undergraduates:
(Dual-listed with TOX 401). (3-0) Cr. 3. F.
Prereq: BBMB 404 or equivalent
Principles of toxicology governing entry, fate, and effects of toxicants on living systems. Includes toxicokinetics and foreign compound metabolism relative to toxification or detoxification. Fundamentals of foreign compound effects on metabolism, physiology, and morphology of different cell types, tissues, and organ systems.
(0-6) Cr. 3. Alt. S., offered even-numbered years.
Prereq: TOX 501
Provides demonstrations or laboratory experience in the application of methods used in toxicology, including safety procedures, calculation and data analysis, teratologic and morphologic evaluation, cellular/molecular toxicological techniques, electrophysiologic measures, in vitro enzyme induction/biotransformation, neural and behavioral toxicology testing.
(1-0) Cr. 1. Repeatable, maximum of 2 credits. F.S.SS.
Prereq: Permission of instructor required
Presentation of a seminar about a current topic in toxicology as part of a weekly series of seminars by graduate students, faculty, and guest lecturers from off campus. Graduate student speakers will meet with the instructor at least one week prior to their formal presentation.
(Cross-listed with NUTRS). (1-0) Cr. 1. Alt. F., offered even-numbered years.
Prereq: BBMB 404 and BBMB 405 or BBMB 420
Principles of cancer biology and cancer etiology will be integrated with the impacts of diet on cancer development and prevention. Contributions of research with humans, animals, cultured cells and cell free systems will be included. The importance of dietary contaminants, macronutrients and micronutrients will be examined with an emphasis on the strength of the evidence and mechanisms of action.
(1-0) Cr. 1. Alt. F., offered even-numbered years.
Prereq: BBMB 404 or FSHN 403
Survey of approaches used by toxicologists in government and industry for generating, enforcing and complying with laws and regulations. Regulatory policies and decision making. Toxicological risk assessment and risk analysis. Taught online only.
(Cross-listed with FS HN, NUTRS). (3-0) Cr. 3. Alt. F., offered even-numbered years.
Prereq: A course in biochemistry
Basic principles of toxicology. Toxicants in the food supply: modes of action, toxicant defense systems, toxicant and nutrient interactions, risk assessment. Assessed service learning component.
Only one of FS HN 419 and FS HN 519 may count toward graduation.
(Dual-listed with TOX 426). (Cross-listed with VDPAM). (3-0) Cr. 3. S.
Prereq: Third year classification in veterinary medicine
Study of toxicological diseases of animals emphasizing clinical recognition, circumstances of poisoning, differential diagnosis with clinical and laboratory data, therapeutic procedures, preventive management and public health implications. Supplemented with case-based materials.
(Cross-listed with FS HN). (2-0) Cr. 2. F.
Prereq: A course in biochemistry; enrollment in GP-IDEA Food Safety and Defense Graduate Certificate or permission of instructor.
Mechanisms of action, metabolism, sources, remediation/detoxification, risk assessment of major foodborne toxicants of current interest, design of HAACP plans for use in food industries targeting foodborne toxicants, discussion of toxicants from a food defense perspective. Offered online only.
(Cross-listed with VDPAM). (0-3) Cr. 1-3. Repeatable. F.S.SS.
Prereq: D.V.M. degree or VDPAM 526
Advanced study of current problems and issues in toxicology. Emphasis on problem solving utilizing clinical, epidemiological, and laboratory resources.
(Cross-listed with ENT). (2-0) Cr. 2. S.
Prereq: 9 credits of biological sciences
Fate and significance of pesticides in soil, water, plants, animals, and the atmosphere.
(Cross-listed with STAT). (3-0) Cr. 3. Alt. F., offered even-numbered years.
Prereq: STAT 500 or STAT 401; STAT 543 or STAT 447
Statistical methods commonly used in epidemiology and human and animal health studies. Overview of cohort studies, case-control studies and randomized clinical trials. Topics include inference procedures for disease risk factors, analysis of time-to-event and survival data, analysis of longitudinal studies of disease progression and health status, diagnostic test evaluation, and meta-analysis. Examples will come from recent studies of physical and mental health, nutrition and disease progression in human and animal populations. Use of statistical software: SAS or R.
(Cross-listed with AGRON, VDPAM). (3-0) Cr. 3. F.
Prereq: Statistics 300-level or higher.
Risk assessment principles as applied to biological systems. Exposure and effects characterization in human and animal health and ecological risk assessment. Risk analysis frameworks and regulatory decision-making. Introduction to quantitative methods for risk assessment using epidemiological and distributional analysis. Uncertainty analysis.
(Cross-listed with B M S). (3-0) Cr. 3. F.
Prereq: 10 credits in biological science and permission of instructor
A multi-instructor course covering major topics in cell structure and function, including: universal features of prokaryotic and eukaryotic cells, types of utilization and conversion of energy, genetic control of cell shape and functionality, internal organization of cells, communication between cells and their environment, development of multicellular systems. Students have to write a term paper.
Cr. arr. Repeatable.
Contact individual faculty for special projects or topics. Graded.
Courses for graduate students:
(Cross-listed with FS HN, MICRO). (3-0) Cr. 3. Alt. F., offered odd-numbered years.
Prereq: FS HN 420 or FS HN 421 or FS HN 504
Topics of current interest in food microbiology, including new foodborne pathogens, rapid identification methods, effect of food properties and new preservation techniques on microbial growth, and mode of action of antimicrobials.
(Cross-listed with FS HN, MICRO). (2-0) Cr. 2. Alt. F., offered even-numbered years.
Prereq: FS HN 420 or FS HN 421 or FS HN 504
Provides an overview of rapid microbial detection methods for use in foods. Topics include historical aspects of rapid microbial detection, basic categories of rapid tests (phenotypic, genotypic, whole cell, etc.), existing commercial test formats and kits, automation in testing, sample preparation and "next generation" testing formats now in development.
(Cross-listed with V PTH). (3-0) Cr. 3. Alt. S., offered even-numbered years.
Prereq: Graduate course in biochemistry, genetics, or cell biology
Cellular and molecular mechanisms of carcinogenesis.
Cr. R. Repeatable. F.S.
Lecture and discussion participation on current topics in toxicology. An 80% attendance is expected to satisfactorily complete the course.
Offered on a satisfactory-fail basis only.
(0-12) Cr. 1-12. Repeatable, maximum of 3 times. F.S.SS.
Prereq: Admission to Toxicology graduate program
Graduate research projects performed under the supervision of selected faculty members in the graduate Toxicology major.
Cr. arr. Repeatable. F.S.SS.
Research.