Genetics, Development and Cell Biology (GDCB)

(3-0) Cr. 3. Alt. F., offered even-numbered years.

High level success at modern science requires entrepreneurship both in and outside the laboratory. Scientists are in a unique position to not only think, but to thrive, "outside of the box" and take unorthodox approaches to research that lead to positive paradigm shifts in our lives. Exploration of many facets of science, technology, industry and commerce, with frequent guest lectures from entrepreneurs.

(3-0) Cr. 3. F.

Prereq: GEN 410 or graduate standing
In-depth investigations of modern research practices of transmission genetics. Designed for students interested in genetic research. Topics include: Mendelian genetic analysis, analysis of genetic pathways, mutational analysis of gene function, chromosomal mechanics, genetic mapping, epigenetic inheritance, human genetic analysis.

(Cross-listed with MCDB). (3-0) Cr. 3. S.

Prereq: BIOL 313 and BBMB 405
Mechanisms of molecular genetic processes in eukaryotes and prokaryotes, including DNA replication and repair, transcription, translation and regulation of gene expression. Critical evaluation and discussion of current primary literature, methodologies and experimental data.

(Cross-listed with PLBIO). (2-0) Cr. 2. Alt. F., offered even-numbered years.

Prereq: BIOL 330, PHYS 111, CHEM 331; one semester of biochemistry recommended
Photosynthesis, respiration, and other aspects of plant metabolism.

(Cross-listed with MCDB). (3-0) Cr. 3. Alt. F., offered even-numbered years.

Prereq: Courses in general cell biology and biochemistry
Cell biological processes including cell signaling, cell division, intracellular trafficking, biogenesis of organelles, cell adhesion and motility.

(Cross-listed with MCDB). (3-0) Cr. 3. Alt. F., offered odd-numbered years.

Prereq: BIOL 314 or BIOL 423
Fundamental principles in multicellular development. Emphasis on cellular and molecular regulation of developmental processes, and experimental approaches as illustrated in the current literature.

(Cross-listed with STAT). (3-0) Cr. 3.

Prereq: STAT 401, STAT 447; GEN 320 or BIOL 313
Statistical models and methods for genetics covering models of population processes: selection, mutation, migration, population structure, and linkage disequilibrium, and inference techniques: genetic mapping, linkage analysis, and quantitative trait analysis. Applications include genetic map construction, gene mapping, genome-wide association studies (GWAS), inference about population structure, phylogenetic tree construction, and forensic and paternity identification.

(Cross-listed with B M S, EEOB, FS HN, HORT, NREM, NUTRS, V MPM, VDPAM). Cr. 1. Repeatable. F.S.SS.

Sessions in basic molecular biology techniques and related procedures. Offered on a satisfactory-fail basis only.

(Cross-listed with B M S, BBMB, EEOB, FS HN, HORT, NREM, NUTRS, V MPM, VDPAM). Cr. 1. Repeatable. F.S.

Includes genetic engineering procedures, sequencing, PCR, and genotyping. Offered on a satisfactory-fail basis only.

(Cross-listed with B M S, BBMB, EEOB, FS HN, HORT, NREM, NUTRS, VDPAM). Cr. 1. Repeatable. S.SS.

Prereq: Graduate classification
Techniques. Includes: fermentation, protein isolation, protein purification, SDS-PAGE, Western blotting, NMR, confocal microscopy and laser microdissection, Immunophenotyping, and monoclonal antibody production. Sessions in basic molecular biology techniques and related procedures. Offered on a satisfactory-fail basis only.

(Cross-listed with B M S, BBMB, EEOB, FS HN, HORT, NREM, NUTRS, V MPM, VDPAM). Cr. 1. Repeatable. F.S.

Includes: immunophenotyping, ELISA, flow cytometry, microscopic techniques, image analysis, confocal, multiphoton and laser capture microdissection. Offered on a satisfactory-fail basis only.

(Cross-listed with B M S, BBMB, EEOB, FS HN, HORT, NREM, NUTRS, V MPM, VDPAM). Cr. 1. Repeatable. S.

Includes: Agrobacterium and particle gun-mediated transformation of tobacco, Arabidopsis, and maize, and analysis of tranformants. Offered on a satisfactory-fail basis only.

(Cross-listed with B M S, BBMB, EEOB, FS HN, HORT, NREM, NUTRS, V MPM, VDPAM). Cr. 1. Repeatable. F.

Includes: two-dimensional electrophoresis, laser scanning, mass spectrometry, and database searching. Offered on a satisfactory-fail basis only.

(Cross-listed with B M S, BBMB, EEOB, FS HN, HORT, NREM, NUTRS, V MPM, VDPAM). Cr. 1. Repeatable. F.

Includes: metabolomics and the techniques involved in metabolite profiling. For non-chemistry majoring students who are seeking analytical aspects into their biological research projects. Offered on a satisfactory-fail basis only.

(Cross-listed with B M S, BBMB, EEOB, FS HN, HORT, NREM, NUTRS, V MPM, VDPAM). Cr. 1. Repeatable. S.

Offered on a satisfactory-fail basis only.

(Cross-listed with BCB, COM S, CPR E). (4-0) Cr. 4. F.

Prereq: MATH 165 or STAT 401 or equivalent
A practical, hands-on overview of how to apply bioinformatics to biological research. Recommended for biologists desiring to gain computational molecular biology skills. Topics include: sequence analysis, genomics, proteomics, phylogenetic analyses, ontology enrichment, systems biology, data visualization and emergent technologies.

(Cross-listed with MCDB, PLBIO). (3-0) Cr. 3. Alt. F., offered odd-numbered years.

Prereq: BIOL 313, BIOL 314, BIOL 330 or BBMB 405
Plant nuclear and organelle genomes; regulation of gene expression; hormone signaling; organization, function, and development of plant cells and subcellular structures; regulation of plant growth and development.

(Cross-listed with B M S, NEURO). (3-0) Cr. 3. Alt. F., offered odd-numbered years.

Prereq: BIOL 335 or BIOL 436; physics recommended
Fundamental principles of neuroscience including cellular and molecular neuroscience, nervous system development, sensory, motor and regulatory systems.

(Cross-listed with NEURO). (3-0) Cr. 3. Alt. S., offered odd-numbered years.

Prereq: NEURO 556 or equivalent course
Research methods and techniques; lectures, laboratory exercises and/or demonstrations representing individual faculty specialties.

(Cross-listed with BCB, COM S, STAT). (3-0) Cr. 3. S.

Prereq: BCB 567 or (BIOL 315 and STAT 430), credit or enrollment in GEN 409
Statistical models for sequence data, including applications in genome annotation, motif discovery, variant discovery, molecular phylogeny, gene expression analysis, and metagenomics. Statistical topics include model building, inference, hypothesis testing, and simple experimental design, including for big data/complex models.

(Cross-listed with BBMB, BCB, COM S, CPR E). (3-0) Cr. 3. F.

Prereq: BCB 567, BBMB 316, GEN 409, STAT 430
Molecular structures including genes and gene products: protein, DNA and RNA structure. Structure determination methods, structural refinement, structure representation, comparison of structures, visualization, and modeling. Molecular and cellular structure from imaging. Analysis and prediction of protein secondary, tertiary, and higher order structure, disorder, protein-protein and protein-nucleic acid interactions, protein localization and function, bridging between molecular and cellular structures. Molecular evolution.

(Cross-listed with BCB, COM S, CPR E, STAT). (3-0) Cr. 3. S.

Prereq: BCB 567 or COM S 311, COM S 228, GEN 409, STAT 430
Algorithmic and statistical approaches in computational functional genomics and systems biology. Analysis of high throughput biological data obtained using system-wide measurements. Topological analysis, module discovery, and comparative analysis of gene and protein networks. Modeling, analysis, and inference of transcriptional regulatory networks, protein-protein interaction networks, and metabolic networks. Dynamic systems and whole-cell models. Ontology-driven, network based, and probabilistic approaches to information integration.

(Cross-listed with BCB, M E). Cr. 4. F.

Prereq: Acceptance into the P3 program or instructor permission.
Principles of engineering, data analysis, and plant sciences and their interplay applied to predictive plant phenomics. Transport phenomena, sensor design, image analysis, graph models, network data analysis, fundamentals of genomics and phenomics. Multidisciplinary laboratory exercises. None

Cr. arr. Repeatable.

Prereq: Permission of instructor

(Cross-listed with BBMB, NEURO). (2-0) Cr. 2-3. Repeatable. Alt. S., offered even-numbered years.

Prereq: NEURO 556 (or comparable course) or permission of instructor
Topics may include molecular and cellular neuroscience, neurodevelopment, neuroplasticity, neurodegenerative diseases, cognitive neuroscience, sensory biology, neural integration, membrane biophysics, neuroethology, techniques in neurobiology and behavior.

Cr. 1. Repeatable.

Research seminars by faculty, invited speakers, and graduate students. Offered on a satisfactory-fail basis only.

Cr. 1. Repeatable.

Faculty research series.

(Cross-listed with AGRON, BBMB, FOR, HORT, PLBIO). Cr. 1. Repeatable.

Research seminars by faculty and graduate students. Offered on a satisfactory-fail basis only.

(Cross-listed with BBMB, MCDB, MICRO, V MPM). (2-0) Cr. 1-2. Repeatable. F.S.

Student and faculty presentations.

Cr. arr. Repeatable.

Research for thesis or dissertation. Offered on a satisfactory-fail basis only.

(Cross-listed with A ECL, ANTHR, EEOB, IA LL). Cr. 1-4. Repeatable.