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Biochemistry (AGLS)

This is an archived copy of the 2023-2024 catalog. To access the most recent version of the catalog, please visit http://catalog.iastate.edu.

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The Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology offers majors in biochemistry in the College of Liberal Arts and Sciences and in the College of Agriculture and Life Sciences. Biochemists seek to understand life processes in terms of chemical and physical principles. Students in the biochemistry majors develop foundational analytical skills while exploring frontiers in biotechnology and medicine. Graduates in biochemistry will have a rigorous background in chemistry, biology, and physics. Biochemistry coursework focuses on the development of problem-solving skills, critical thinking, communication, and research design. The Biochemistry degree includes focused specializations towards professional goals, including three prescribed options: Research & Biotechnology, Pre-Medicine, and Biophysics.

Graduates with a Biochemistry B.S. degree will be prepared for postgraduate studies in the chemical or biological sciences, medical and health professional training, or immediate laboratory research in biochemistry, biotechnology, or pharmacy. Graduates are also equipped to pursue careers in teaching, technical writing, science communication and policy, intellectual property law, and biotechnology entrepreneurship. The biochemistry major is accredited by the American Society for Biochemistry and Molecular Biology (ASBMB). As such our learning objectives align with ASBMB core concepts. 

Student Learning Outcomes

Upon graduation, students should be able to:

  • Explain and provide examples to illustrate the biochemical principles underlying the following:
    1. How energy is required and transformed in biological systems.
    2. How macromolecular structure determines function and regulation.
    3. How information storage and flow are dynamic and interactive.
    4. How biochemistry and biology are driven by evolution and homeostasis
  • Apply and justify appropriate techniques to characterize and quantify biomolecules in biological systems.
  • Execute effective multimodal communication of the research process and results.
  • Implement and justify best practices for laboratory safety and research ethics.

College of Agriculture and Life Sciences Learning Outcomes

Graduates with a Biochemistry B.S. degree from the College of Agriculture and Life Sciences should be able to:

  • Explain the role of biochemistry in biotechnology entrepreneurship, pharmaceuticals, agriculture, and allied fields.
  • Demonstrate collaboration and leadership in research teams.
  • Explain biochemical cycles that impact global ecosystems.

Biochemistry Major in the College of Agriculture and Life Sciences

The Bachelor of Science (B.S.) degree in Biochemistry requires the Biochemistry Core and one of the following three prescribed options. The options represent focused specializations for professional goals, including Research & Biotechnology, Pre-Medicine, and Biophysics. As majors in the College of Agriculture and Life Sciences, Biochemistry students must meet College of Agriculture and Life Sciences and University-wide requirements for graduation in addition to those stated below. Focus option-approved science electives can be found on the Biochemistry website.

Total Degree Requirement: 120 cr.

CALS majors require a minimum of 120 credits, including a minimum of 45 credits at the 300/400 level. Only 65 cr. from a two-year institution may apply which may include up to 16 technical cr.; 9 P-NP cr. of free electives; 2.00 minimum GPA.

International Perspective: 3 cr.

3 cr. from approved International Perspective list: http://www.registrar.iastate.edu/students/div-ip-guide/IntlPerspectives-current

U.S. Diversity: 3 cr.

3 cr. from approved U.S. Diversity list: http://www.registrar.iastate.edu/students/div-ip-guide/usdiversity-courses

College of Agriculture and Life Sciences General Education Electives: 9 cr.

Humanities

3 cr. from approved humanities list: http://www.cals.iastate.edu/student-services/humanities 

Social Sciences

3 cr. from approved social sciences list: http://www.cals.iastate.edu/student-services/social-sciences

Ethics

3 cr. from approved ethics list: http://www.cals.iastate.edu/student-services/ethics

Communications Proficiency: 11 cr.

6 cr. of English composition with a C or better and 3 cr. of speech fundamentals with a C or better.

ENGL 150Critical Thinking and Communication3
ENGL 250Written, Oral, Visual, and Electronic Composition3
or ENGL 250H Written, Oral, Visual, and Electronic Composition: Honors
SP CM 212Fundamentals of Public Speaking3
LIB 160Introduction to College Level Research1
BBMB 311Writing Scientific Reports in Biochemistry *1
*BBMB 311 fulfills the upper-level Communications Proficiency Requirement
Total Credits11

Biochemistry Core

The major in biochemistry requires completion of the Biochemistry Core and one of three focus options. Each defined option includes specific supporting coursework in Biology; Chemistry; Mathematics and/or Statistics. 

BBMB 101Introduction to Biochemistry1
BBMB 102Introduction to Biochemistry Laboratory1
BBMB 201Chemical Principles in Biological Systems2
BBMB 311Writing Scientific Reports in Biochemistry 11
BBMB 312Experimental Research Skills in Biochemistry2
BBMB 404Biochemistry I3-4
or BBMB 504
BBMB 505
Amino Acids and Proteins
and Bioenergetics and Metabolism
BBMB 405Biochemistry II3-4
or BBMB 506
BBMB 507
Membrane Biochemistry
and Biochemistry of Nucleic Acids
BBMB 410Analysis of Scientific Literature2
BBMB 411Techniques in Biochemical Research4
BBMB 461Molecular Biophysics2
BBMB 561LLaboratory in Molecular Biophysics2-3
or CHEM 322L Laboratory in Physical Chemistry
PHYS 231
231L
Introduction to Classical Physics I
and Introduction to Classical Physics I Laboratory
5
PHYS 232
232L
Introduction to Classical Physics II
and Introduction to Classical Physics II Laboratory
5
BBMB 499Undergraduate Research (highly encouraged elective)arr †
Total Credits33-36 †
† Arranged with instructor.
1

BBMB 311 fulfills the ISU upper-level Communication Proficiency requirement.


Biochemistry Program of Study: Research & Biotechnology
Students interested in careers in biotechnology research and/or graduate studies in biochemistry, chemistry, or bioscience fields may opt for the Research & Biotechnology Option. The College of Agriculture and Life Sciences (CALS) electives allow specialization in agricultural biochemistry or plant biochemistry.

In addition to the Biochemistry Core (above):
CHEM 201Advanced General Chemistry5-7
or CHEM 177
CHEM 178
General Chemistry I
and General Chemistry II
CHEM 201LLaboratory in Advanced General Chemistry1
or CHEM 177N Laboratory in General Chemistry I
or CHEM 177L Laboratory in General Chemistry I
CHEM 325Chemical Thermodynamics3
CHEM 331Organic Chemistry I3
CHEM 332Organic Chemistry II3
CHEM 333LLaboratory in Organic Chemistry I (for Chemistry and Biochemistry Majors)1-2
or CHEM 331L Laboratory in Organic Chemistry I
CHEM 334LLaboratory in Organic Chemistry II (for Chemistry and Biochemistry Majors)1-2
or CHEM 332L Laboratory in Organic Chemistry II
MATH 165
MATH 166
Calculus I
and Calculus II
8
STAT 201Introduction to Statistical Concepts and Methods4
or STAT 305 Engineering Statistics
BIOL 211Principles of Biology I3
BIOL 212Principles of Biology II3
BIOL 313
313L
Principles of Genetics
and Genetics Laboratory
4
BIOL 314Principles of Molecular Cell Biology3
Agricultural & Molecular Sciences from approved list9
Total Credits51-55

Biochemistry Program of Study: Pre-Medicine
Students interested in qualifying for medical school training for careers as a Doctor of Medicine (MD) or Doctor of Osteopathic Medicine (DO) may opt for the Pre-Medicine Option. Allied health professions (e.g., Physician Assistant, Dentistry, and Ophthalmology) may also consider the Pre-Medicine Option. The CALS option is especially suited to careers in Veterinary Medicine.

In addition to the Biochemistry Core (above):
CHEM 177
177L
CHEM 178
CHEM 178L
General Chemistry I
and Laboratory in General Chemistry I
and General Chemistry II
and Laboratory in College Chemistry II
6-9
or CHEM 201
201L
Advanced General Chemistry
and Laboratory in Advanced General Chemistry
CHEM 325Chemical Thermodynamics3
CHEM 331
331L
Organic Chemistry I
and Laboratory in Organic Chemistry I
4
CHEM 332
332L
Organic Chemistry II
and Laboratory in Organic Chemistry II
4
MATH 165
MATH 166
Calculus I
and Calculus II
8
STAT 201Introduction to Statistical Concepts and Methods3-4
or STAT 305 Engineering Statistics
PSYCH 101Introduction to Psychology3
or PSYCH 230 Developmental Psychology
SOC 134Introduction to Sociology3
BIOL 211Principles of Biology I3
BIOL 211LPrinciples of Biology Laboratory I1
BIOL 212Principles of Biology II3
BIOL 212LPrinciples of Biology Laboratory II1
BIOL 313Principles of Genetics3
BIOL 314Principles of Molecular Cell Biology3
Physiology & Bioscience Electives from approved list6
Total Credits54-58

Biochemistry Program of Study: Biophysics
Students interested in research careers focused on the biophysical basis of life processes may opt for the Biophysics Option. The CALS electives offer specialization in agricultural biophysics or plant biophysics.

In addition to the Biochemistry Core (above):
CHEM 201Advanced General Chemistry5-7
or CHEM 177
CHEM 178
General Chemistry I
and General Chemistry II
CHEM 201LLaboratory in Advanced General Chemistry1
or CHEM 177N Laboratory in General Chemistry I
or CHEM 177L Laboratory in General Chemistry I
CHEM 324Introductory Quantum Mechanics3
CHEM 325Chemical Thermodynamics3
CHEM 331Organic Chemistry I3
CHEM 332Organic Chemistry II3
MATH 165
MATH 166
Calculus I
and Calculus II
8
MATH 265Calculus III4
MATH 266Elementary Differential Equations3
MATH 317Theory of Linear Algebra4
STAT 201Introduction to Statistical Concepts and Methods4
or STAT 305 Engineering Statistics
or STAT 231 Probability and Statistical Inference for Engineers
COM S 207Fundamentals of Computer Programming3
BIOL 211Principles of Biology I3
BIOL 212Principles of Biology II3
Agricultural & Physical Sciences from approved list6
Total Credits56-58

Four Year Plans

Biochemistry B.S. Program of Study, College of Agriculture and Life Sciences
Research & Biotechnology Option
Sample Four-Year Plan

First Year
FallCreditsSpringCredits
BBMB 1011BBMB 1021
BBMB 1101BBMB 1111
MATH 1654MATH 1664
CHEM 1774CHEM 1783
CHEM 177N1BIOL 2113
LIB 1601SP CM 2123
ENGL 1503 
 15 15
Second Year
FallCreditsSpringCredits
MATH 265, 266, 267, STAT 201, or STAT 3053-4BBMB 2012
CHEM 3313CHEM 3323
CHEM 331L1CHEM 332L1
PHYS 2314PHYS 2324
PHYS 231L1PHYS 232L1
BIOL 2123ENGL 2503
 BBMB 4991
 15-16 15
Third Year
FallCreditsSpringCredits
BBMB 4043BBMB 4053
BBMB 311*1BIOL 3143
BBMB 3122BBMB 4102
BIOL 3133BBMB 4992
BIOL 313L1International Perspectives Elective3
BBMB 4992General Education Elective3
General Education Elective3 
 15 16
Fourth Year
FallCreditsSpringCredits
BBMB 4114CHEM 3253
Upper-level Agriculture or Mol. Sci. Elective3CHEM 322L or BBMB 461 and BBMB 561L3-4
Upper-level Agriculture or Mol. Sci. Elective3BBMB 4992
BBMB 4992Upper-level Agriculture or Mol. Sci. Elective3
General Education Elective3U.S. Diversity Elective3
 15 14-15
 

"General Education Electives" include 3 credits each in Humanities, Ethics, and Social Sciences.

*

BBMB 311 fulfills the upper-level communication proficiency requirement.


Biochemistry B.S. Program of Study, College of Agriculture and Life Sciences
Pre-Medicine Option
Sample Four-Year Plan

First Year
FallCreditsSpringCredits
BBMB 1011BBMB 1021
BBMB 1101BBMB 1111
MATH 1654MATH 1664
CHEM 1774CHEM 1783
CHEM 177N1CHEM 178L1
LIB 1601BIOL 2113
ENGL 1503BIOL 211L1
 15 14
Second Year
FallCreditsSpringCredits
BIOL 2123BBMB 2012
BIOL 212L1CHEM 3323
CHEM 3313CHEM 332L1
CHEM 331L1PHYS 2324
PHYS 2314PHYS 232L1
PHYS 231L1ENGL 2503
PSYCH 1013 
 16 14
Third Year
FallCreditsSpringCredits
BBMB 4043BBMB 4053
BBMB 311*1BIOL 3143
BBMB 3122BBMB 4102
BIOL 3133BBMB 4992
STAT 2014SOC 1343
General Education Elective3International Perspectives Elective3
 16 16
Fourth Year
FallCreditsSpringCredits
BBMB 4114CHEM 3253
Upper-level Upper-level Physiology & Biosci. Elective3CHEM 322L or BBMB 461 and BBMB 561L3-4
BBMB 4992BBMB 4992
SP CM 2123Upper-level Physiology & Biosci. Elective3
General Education Elective3U.S. Diversity Elective3
 15 14-15
 

"General Education Electives" include 3 credits each in Humanities and Ethics. MCAT recommended Soc 134 satisfies the Social Sciences requirement.

*

BBMB 311 fulfills the upper-level communication proficiency requirement.


Biochemistry B.S. Program of Study, College of Agriculture and Life Sciences
Biophysics Option
Sample Four-Year Plan

First Year
FallCreditsSpringCredits
BBMB 1011BBMB 1021
BBMB 1101BBMB 1111
MATH 1654MATH 1664
CHEM 1774CHEM 1783
CHEM 177N1BIOL 2113
LIB 1601SP CM 2123
ENGL 1503 
 15 15
Second Year
FallCreditsSpringCredits
MATH 2654BBMB 2012
CHEM 3313CHEM 3323
PHYS 2314PHYS 2324
PHYS 231L1PHYS 232L1
BIOL 2123ENGL 2503
 BBMB 4991
 International Perspective Elective3
 15 17
Third Year
FallCreditsSpringCredits
BBMB 4043BBMB 4053
BBMB 311*1CHEM 3253
BBMB 3122BBMB 4102
COM S 2073MATH 3174
BBMB 4991BBMB 4992
U.S. Diversity Elective3 
General Education Elective3 
 16 14
Fourth Year
FallCreditsSpringCredits
BBMB 4114CHEM 3243
BBMB 4992CHEM 322L or BBMB 461 and BBMB 561L3-4
STAT 2314BBMB 4993
Upper-level Agricultural or Phys. Elective3Upper-level Agricultural or Phys. Elective3
General Education Elective3General Education Elective3
 16 15-16
 

"General Education Electives" include 3 credits each in Humanities, Ethics, and Social Sciences.

*

BBMB 311 fulfills the upper-level communication proficiency requirement.

The Roy J. Carver Department of Biochemistry, Biophysics, and Molecular Biology offers a minor in Biochemistry.

BBMB 404Biochemistry I3
BBMB 405Biochemistry II3
BBMB 312Experimental Research Skills in Biochemistry2
One course from the following:2-3
Molecular Biophysics (2 cr)
Molecular Biophysics (2 cr)
Chemical Thermodynamics (3 cr)
300+ level courses in BBMB or CHEM to 15 cr total5-6
Total Credits15-17

All minors require at least 15 credits, including at least 6 credits in course numbered 300 or above taken at Iowa State University. The minor must include at least 9 credits that are not used to meet any other department, college, or university requirement.

Concurrent Bachelor of Science (B.S.)/ Master of Science (M.S.) Degrees

The department offers a concurrent enrollment degree program in either Biochemistry or Biophysics that allows ISU undergraduate students to obtain both the B.S. and M.S. degrees in about five years. The program is open to undergraduate students in the College of Liberal Arts and Sciences and in the College of Agriculture and Life Sciences.  The concurrent degrees can be useful to students entering various career tracks. For those considering careers as research specialists, entry positions with higher-level responsibilities, and a higher-level salary, are made possible with the M.S. degree. For those considering careers as research directors, which require advanced study, the M.S. degree provides an advantage for admission into Ph.D. programs at the most competitive and prestigious graduate schools. Similarly, the M.S. degree can be a competitive advantage for admission in to medical, dental, law, veterinary medicine, or other professional schools.

Application to the program is made near the end of the junior undergraduate (third) year.  Concurrent B.S/M.S. degree students begin research for the M.S. thesis during the summer semester after their junior year and are eligible for research assistantships, which are renewable based on academic standing and satisfactory research performance. The M.S. thesis requires intensive experience in original, independent laboratory research under the close supervision of a faculty mentor. To apply, see the concurrent B.S./M.S. application instructions found on the department’s Graduate Study web page.

Concurrent Bachelor of Science/Graduate Certificate

The Bachelor of Science /Graduate Certificate program is intended for exceptional undergraduate students majoring in Biochemistry. In this program, the student completes all of the requirements for the B.S. degree and the graduate certificate in a four-year period by combining the requirements of the two programs. The student enters the Graduate College after he/she achieves junior status and develops a plan of coursework (graduate and undergraduate) subject to the approval of the Director of Certificate (DOC). Required graduate courses are BBMB 504, BBMB 505, BBMB 506, BBMB 507, BBMB 561 and BBMB 561L. The student must satisfy the requirements of the B.S. in Biochemistry (121 credits) and the Graduate Certificate in Biochemistry (12 credits). Six credits of graduate coursework can satisfy some requirements of the B.S. degree. To apply for the B.S./Graduate Certificate, submit the application form found on the Graduate College Forms web page.

Biochemistry and Biophysics are the science and technology used to understand the mechanisms underlying biological processes at the molecular level, with an emphasis on the fundamental relationships among the chemical, physical, and biological sciences. The Roy J. Carver Department of Biochemistry, Biophysics, and Molecular Biology (BBMB) administers Doctor of Philosophy (Ph.D.), Master’s (M.S.), and Graduate Certificate programs that lead to an advanced degree or certificate in these disciplines.  The prerequisite to graduate study is a sound undergraduate background in biology, chemistry, mathematics, and physics.

BBMB offers Doctor of Philosophy and Master’s degrees in Biochemistry and in Biophysics that are designed to train students to independently conceive and carry out original research. BBMB also offers two graduate certificate programs in Biochemistry that provide a mechanism for formal recognition of focused graduate study in a specialized area that is less comprehensive than that required for a master's degree. BBMB participates in the Interdepartmental majors of Bioinformatics and Computational Biology; Genetics and Genomics; Immunobiology; Molecular, Cellular, and Developmental Biology; Neuroscience; Plant Biology; and Toxicology.  All graduate degree students in BBMB are required to teach as part of their training.

Master’s (M.S.) Degree

The M.S. degree programs in Biochemistry and in Biophysics are useful for students who prefer to undertake research training without the longer-term commitment required for the Ph.D. degree.  It is also useful for students interested more in the technical aspects of research rather than in careers as research directors.  The program requires about 3 years on average to complete and the successful defense of an independent research dissertation is required.  About half the time required to earn the degree is spent on advanced coursework and professional seminars, and the other half is devoted to research undertaken in the laboratory under the close supervision of a faculty mentor.  Financial support is available.  To apply, applicants first submit the free BBMB online application found on the department website, which is used as a screening tool.

NOTE: Students interested in a research career are encouraged to consider the Ph.D. track. Students may enter the Biochemistry or Biophysics M.S. degree program as a direct admit to a faculty research group at any time during the year.

Doctor of Philosophy (Ph.D.) Degree

The Ph.D. programs in Biochemistry and in Biophysics are designed to train students in the ability to independently conceive and carry out original research in the general area of the chemistry or physics of the processes of life.  The programs require about 5-6 years on average to complete and the successful defense of an independent research dissertation.  The majority of the time required to earn the degree is spent doing research on the dissertation project in the laboratory under the close supervision of a faculty mentor.  Considerable time also is devoted to advanced coursework and professional seminars. Financial support is available.  To apply, applicants first submit the free BBMB online application found on the department website, which is used as a screening tool. Students may enter the Biochemistry or Biophysics Ph.D. degree programs either as a rotation student in the fall semester or as a direct admit to a faculty research group at any time during the year.

Minor in Biochemistry

Graduate students in other M.S. and/or Ph.D. programs at ISU can earn a graduate minor in Biochemistry by completing 12 credits of the following courses with a grade point average of 3.0 or above: at least 6 credits from BBMB 504, BBMB 505, BBMB 506 and BBMB 507 and at least 6 credits of other BBMB 500- and 600-level courses.  A student wishing to declare a minor in Biochemistry should arrange for a member of the graduate faculty in Biochemistry to serve on the POS Committee and submit the required form found on the Graduate College Forms page.

Graduate Certificate in Biochemistry

The graduate certificate in Biochemistry is designed for students who have a B.S. degree in Biochemistry or a related field and wish to advance their knowledge by taking additional coursework at the graduate level.  The graduate certificate courses may be taken either on-line or on campus.  Candidates for a graduate certificate in Biochemistry are admitted in the Graduate College. A total of 12 credits is required that include BBMB 504, BBMB 505, BBMB 506 and BBMB 507, plus four additional credits of BBMB coursework at the 500-level. The 12 credits earned in the graduate certificate program may be applied to meet the course requirements of a M.S. or Ph.D. program in Biochemistry at Iowa State University (ISU) if the student is accepted into one of these programs. To apply for the graduate certificate in Biochemistry, submit the ISU online application.