Biochemistry, Biophysics, and Molecular Biology (BBMB)

Credits: 1. Contact Hours: Lecture 1.

Foundational principles of the molecules and chemistry of life, including structure and function of biological molecules: protein, lipids, nucleic acids, and carbohydrates. Survey of modern biotechnology frontiers. (Typically Offered: Fall)

Credits: 1.

Prereq: Credit or enrollment in CHEM 1770 and CHEM 1770L or CHEM 2010 and CHEM 2010L
Topics in the scientific background of biochemistry, such as macromolecules, metabolism, and catalysis. Laboratory experimentation covers biochemical concepts and the study of bio-molecules including proteins, lipids and nucleic acids. A significant component is practice in scientific communication. For students declaring or considering Biochemistry majors. (Typically Offered: Spring)

Credits: 1. Contact Hours: Lecture 1.

Biochemistry Learning Community introducing the program of study, academic planning, and university resources. Survey of careers and research in biotechnology, medicine, and biophysics. Introduction to ISU research and faculty. Concurrent enrollment with BBMB 1010 highly recommended. Offered on a satisfactory-fail basis only. (Typically Offered: Fall)

Credits: 1. Contact Hours: Lecture 1.

Biochemistry Learning Community serving an overview of career-development and research resources, including research opportunities, internships, lab skills, and leadership roles. Introductions to ISU research and faculty. Offered on a satisfactory-fail basis only. (Typically Offered: Spring)

(Cross-listed with FSHN 1200).
Credits: 2. Contact Hours: Lecture 2.

An introduction to the major classes of biomolecules, basic biochemical concepts, enzymology, metabolism and genetic engineering as they apply to the production and flavor of beer. All aspects of the biochemistry of beer will be covered, including the malting of barley, starch conversion, yeast fermentation and the chemical changes that occur during the aging of beer. Intended for non-majors. (Typically Offered: Fall)

(Cross-listed with FSHN 1200L).
Credits: 1. Contact Hours: Laboratory 3.

Prereq: Credit or enrollment in BBMB 1200
An introduction to biochemical methods related to the production of beer. Laboratory exercises related to water chemistry, mash enzymology, hop compound extraction and analysis, and yeast biology will be performed. Closely follows the material being taught in BBMB 1200. Graduation Restriction: Natural science majors are limited to elective credit only.

Credits: 2. Contact Hours: Lecture 2.

An introduction to how medicines treat disease, what drug molecules look like, how they function, how they can be toxic, modern therapeutics ranging from over-the-counter pain relievers, antibiotics and anti-depressants, to anti-cancer chemotherapies. The differences between drugs and supplements. Intended for students of all majors. (Typically Offered: Spring)

Credits: 2. Contact Hours: Lecture 2.

Prereq: Credit or enrollment in CHEM 3320
Survey of the chemical principles of biological systems including: water, organic chemistry of functional groups in biomolecules and biochemical cofactors, weak bonds and their contribution to biomolecular structure, oxidation-reduction reactions and redox potential, thermodynamic laws and bioenergetics, chemical equilibria and kinetics, inorganic chemistry in biological systems, data presentation. The subjects will be taught using molecules from biological systems as examples. Intended for majors in biochemistry. (Typically Offered: Spring)

Credits: 3. Contact Hours: Lecture 3.

Prereq: CHEM 1630, CHEM 1670, CHEM 1770 or CHEM 2010
Fundamentals necessary for an understanding of biochemical processes. Primarily for students in agriculture. Graduation Restriction: Not acceptable for credit toward a major in biochemistry, biophysics, or agricultural biochemistry. Credit for both BBMB 2210 and CHEM 2310 may not be applied toward graduation. (Typically Offered: Fall, Spring)

Credits: 3. Contact Hours: Lecture 3.

Prereq: CHEM 2310 or CHEM 3310
A survey of biochemistry: structure and function of amino acids, proteins, carbohydrates, lipids, and nucleic acids; enzymology; metabolism; biosynthesis; and selected topics. Graduation Restriction: Only one of BBMB 3010, 3030, or 3160 may count toward graduation; Not acceptable for credit toward a major in Biochemistry. (Typically Offered: Fall, Spring, Summer)

Credits: 3. Contact Hours: Lecture 3.

Prereq: CHEM 3310
Survey of biochemistry for Engineering majors: structure and function of amino acids, proteins, carbohydrates, lipids and nucleic acids; enzyme activity; metabolism; DNA replication; RNA transcription; protein translation; with case studies examining industrial uses. Graduation Restriction: Only one of BBMB 3010, 3030, or 3160 may count toward graduation; Not acceptable for credit toward a major in Biochemistry. (Typically Offered: Fall)

Credits: 1.

Prereq: Credit or concurrent enrollment in BBMB 3120
Data analysis, presentation, and writing reports in biochemistry. Concurrent enrollment in BBMB 3120 recommended. (Typically Offered: Fall, Spring)

Credits: 2. Contact Hours: Lecture 1, Laboratory 3.

Prereq: BBMB 1020 AND (credit or concurrent enrollment in CHEM 1780 or CHEM 2010)
Inquiry-based introduction to biochemical techniques such as protein purification, enzymatic assays, solution preparation, hypothesis formation and testing, data analysis, high-throughput methodology, and research record keeping. Concurrent enrollment in BBMB 3110 recommended. (Typically Offered: Fall, Spring)

Credits: 3. Contact Hours: Lecture 3.

Prereq: BIOL 3140; (CHEM 2310 or CHEM 3310)
Biological systems at the molecular level; chemistry of biological macromolecules, enzyme function and regulation, basic metabolic pathways; integration of metabolism in diverse living systems. For students in biology and related majors who do not require the more rigorous treatment of biochemistry found in BBMB 4040/4050. Graduation Restriction: Only one of BBMB 3010, 3030, or 3160 may count toward graduation; Not acceptable for credit toward a major in Biochemistry. (Typically Offered: Fall, Spring)

Credits: 3. Contact Hours: Lecture 3.

Prereq: CHEM 2310 or CHEM 3310
Survey of biochemistry for undergraduate majors in biochemistry and related fields. The first of a comprehensive two semester series with BBMB 4050. Chemistry of amino acids, proteins, carbohydrates, and lipids; protein structure, function, and regulation; carbohydrate metabolism. BIOL 3140 strongly recommended. Graduation Restriction: Credit for both BBMB 4200 and the BBMB 4040 - 4050 sequence may not be applied toward graduation. (Typically Offered: Fall, Spring, Summer)

Credits: 3. Contact Hours: Lecture 3.

Prereq: BBMB 4040
Survey of biochemistry for undergraduate majors in biochemistry and related fields. The second of a comprehensive two semester series after BBMB 4040. Metabolism of carbohydrates, amino acids, nucleotides and lipids; formation, turnover, and molecular relationships among DNA, RNA, and proteins; genetic code; regulation of gene expression; and selected topics in molecular physiology. Graduation Restriction: Credit For Either BBMB 420 Or The BBMB 404,405 Sequence, But Not Both, May Be Applied Toward Graduation. (Typically Offered: Fall, Spring, Summer)

Credits: 2. Contact Hours: Lecture 2.
Repeatable, maximum of 2 times.

Prereq: Credit or enrollment in BBMB 4040 or BBMB 5040
Examination and discussion of current research reports in biochemistry, biophysics, genetics, molecular and cell biology. Critical evaluation and analysis of scientific data and experimental design in research literature. (Typically Offered: Fall, Spring)

Credits: 4. Contact Hours: Lecture 2, Laboratory 8.

Prereq: Credit or enrollment in CHEM 3320
Laboratory experimentation and techniques for studying biochemistry, including: chromatographic methods; electrophoresis; spectrophotometry; enzyme purification; enzyme kinetics; and characterization of carbohydrates, proteins, lipids, and nucleic acids. Scientific communication and technical writing are emphasized. (Typically Offered: Fall)

Credits: 3. Contact Hours: Lecture 3.

Prereq: CHEM 3320 and BIOL 3140
Structure and function of proteins; enzymology; biological oxidation; chemistry and metabolism of carbohydrates, lipids, amino acids and nucleic acids; protein synthesis and the genetic code; relationship of biochemistry to selected mammalian diseases. Biochemistry of mammals emphasized. Graduation Restriction: Not acceptable for credit toward a major in Biochemistry. Credit for both BBMB 4200 and the BBMB 4040 - 4050 sequence may not be applied toward graduation. (Typically Offered: Fall, Spring)

(Dual-listed with MICRO 5300). (Cross-listed with MICRO 4300).
Credits: 3. Contact Hours: Lecture 3.

Prereq: MICRO 3020; MICRO 3020L
Survey of the diverse groups of procaryotes emphasizing important and distinguishing metabolic, phylogenetic, morphological, and ecological features of members of those groups. Offered odd-numbered years. (Typically Offered: Spring)

(Dual-listed with BBMB 5450).
Credits: 2. Contact Hours: Lecture 2.

Prereq: BBMB 4050 or BBMB 4200; or BBMB 5060 and BBMB 5070
Molecular mechanisms of cellular signaling including receptor activation, desensitization and cross talk, signal transduction pathways, nuclear receptors, growth factor and extracellular matrix activators, protein kinases, caspase and transcription factor downstream signals, and lipids, gases and cyclic nucleotides as regulators of cell signaling. Course content includes current literature, student and instructor presentations and, for BBMB 5450 students only, research proposal writing and review. Offered even-numbered years. (Typically Offered: Spring)

(Dual-listed with BBMB 5610).
Credits: 2. Contact Hours: Lecture 2.

Prereq: CHEM 1780; PHYS 2320 or PHYS 2320H
Physical methods for the study of molecular structure and organization of biological materials. X-ray diffraction, nuclear magnetic resonance, hydrodynamics and fluorescence spectroscopy. Registration for the graduate credit commits the student to graduate-level examinations, which differ from undergraduate-level examinations in the number and/or difficulty of questions. (Typically Offered: Spring)

Credits: 1-3. Repeatable.

Prereq: Instructor Permission for Course
Independent study with a faculty mentor. Graduation Restriction: No more than 9 credits of BBMB 4900 may count toward graduation. (Typically Offered: Fall, Spring, Summer)

Credits: 1-5. Repeatable.

Prereq: Instructor Permission for Course
Independent research under faculty guidance. (Typically Offered: Fall, Spring, Summer)

Credits: 2. Contact Hours: Lecture 2.

Prereq: Junior, Senior, or Graduate Standing
Protein structure and chemistry including protein folding, examples of enzyme functions and mechanisms, methods of protein expression, purification, and analysis, and elementary enzyme kinetics. (Typically Offered: Fall, Spring)

Credits: 2. Contact Hours: Lecture 2.

Prereq: Junior, Senior, or Graduate Standing
Examination of catabolic pathways involved in the oxidation of organic and inorganic molecules, and energy metabolism involving inputs from light or other non-light sources. Central metabolism and glycolysis, fermentation, aerobic and anaerobic respiration, photosynthesis. (Typically Offered: Fall)

Credits: 2. Contact Hours: Lecture 2.

Prereq: Junior, Senior, or Graduate Standing
Analysis of the structure and functions of biological lipids and membranes. Mechanisms of membrane transport, trafficking, and signaling mechanisms. Investigation of the structures, roles, and biogenesis of transmembrane proteins. (Typically Offered: Fall, Spring)

Credits: 2. Contact Hours: Lecture 2.

Prereq: Junior, Senior, or Graduate Standing
Analysis of the chemical structure, function, synthesis, and metabolism of nucleic acids. Chemical characterization of nucleotides, polynucleotides, DNA, and RNA. Analysis of transcription, translation, and the genetic code. (Typically Offered: Fall, Spring)

Credits: 2. Contact Hours: Lecture 2.

Prereq: Graduate Standing or Permission of Instructor
Biochemical processes that define structure and function of nucleic acids. Emphasis on the molecular processes that take place during synthesis, processing, and function of different RNA species; review of recent advances in RNA research. (Typically Offered: Fall)

Credits: 2. Contact Hours: Lecture 2.

Prereq: Graduate Standing or Permission of Instructor
Structure, synthesis, and functions of glycans, glycoproteins, glycolipids, and glycosylated secondary metabolites in prokaryotic and eukaryotic organisms. Fundamental role of glycans in living organisms along with the most advanced techniques used for their characterization. Biotechnological applications of glycans and glycoconjugates for human needs. Offered even-numbered years. (Typically Offered: Spring)

(Dual-listed with MICRO 4300). (Cross-listed with MICRO 5300).
Credits: 3. Contact Hours: Lecture 3.

Prereq: (MICRO 3020 and MICRO 3020L) or Graduate Classification
In-depth exploration of plant biochemistry with a focus on the unique aspects of plants versus heterotrophic organisms. Analysis of unique pathways, metabolic trafficking between unique organelles and tissues, and techniques for their characterization. Offered even-numbered years. (Typically Offered: Fall)

Credits: 2. Contact Hours: Lecture 2.

Prereq: BBMB 3010
In-depth exploration of plant biochemistry with a focus on the unique aspects of plants versus heterotrophic organisms. Analysis of unique pathways, metabolic trafficking between unique organelles and tissues, and techniques for their characterization. (Typically Offered: Fall)

Credits: 2. Contact Hours: Lecture 2.

Prereq: Graduate Standing or Permission of Instructor
Advanced concepts of enzyme kinetics and catalysis. Experimental methods for determining kinetic and chemical reaction mechanisms. Enzyme structure/function relationships and the role of dynamics in catalysis. Offered odd-numbered years. (Typically Offered: Spring)

(Cross-listed with BMS 5420A/ EEOB 5420A/ FSHN 5420A/ GDCB 5420A/ HORT 5420A/ NREM 5420A/ NUTRS 5420A/ VDPAM 5420A/ VMPM 5420A).
Credits: 1. Contact Hours: Lecture 0.5, Laboratory 1.
Repeatable.

Prereq: Graduate Standing or Permission of Instructor
Includes genetic engineering procedures, sequencing, PCR, and genotyping. Offered on a satisfactory-fail basis only. (Typically Offered: Fall, Spring)

(Cross-listed with BMS 5420B/ EEOB 5420B/ FSHN 5420B/ GDCB 5420B/ HORT 5420B/ NREM 5420B/ NUTRS 5420B/ VDPAM 5420B).
Credits: 1. Repeatable.

Prereq: Graduate Standing or Permission of Instructor
Includes: immunophenotyping, ELISA, flow cytometry, microscopic techniques, image analysis, confocal, multiphoton and laser capture microdissection. Offered on a satisfactory-fail basis only. (Typically Offered: Spring, Summer)

(Cross-listed with BMS 5420C/ EEOB 5420C/ FSHN 5420C/ GDCB 5420C/ HORT 5420C/ NREM 5420C/ NUTRS 5420C/ VMPM 5420C/ VDPAM 5420C).
Credits: 1. Contact Hours: Laboratory 2.
Repeatable.

Prereq: Graduate Standing or Permission of Instructor
Includes: immunophenotyping, ELISA, flow cytometry, microscopic techniques, image analysis, confocal, multiphoton and laser capture microdissection.ular biology techniques and related procedures. Offered on a satisfactory-fail basis only. (Typically Offered: Fall, Spring)

(Cross-listed with BMS 5420D/ EEOB 5420D/ FSHN 5420D/ GDCB 5420D/ HORT 5420D/ NREM 5420D/ NUTRS 5420D/ VMPM 5420D/ VDPAM 5420D).
Credits: 1. Contact Hours: Lecture 0.5, Laboratory 1.
Repeatable.

Prereq: Graduate Standing or Permission of Instructor
Includes: Agrobacterium and particle gun-mediated transformation of tobacco, Arabidopsis, and maize, and analysis of tranformants. Offered on a satisfactory-fail basis only. (Typically Offered: Spring)

(Cross-listed with BMS 5420E/ EEOB 5420E/ FSHN 5420E/ GDCB 5420E/ HORT 5420E/ NREM 5420E/ NUTRS 5420E/ VMPM 5420E/ VDPAM 5420E).
Credits: 1. Contact Hours: Lecture 0.5, Laboratory 1.
Repeatable.

Prereq: Graduate Standing or Permission of Instructor
Includes: two-dimensional electrophoresis, laser scanning, mass spectrometry, and database searching. Offered on a satisfactory-fail basis only. (Typically Offered: Fall)

(Cross-listed with BMS 5420F/ EEOB 5420F/ FSHN 5420F/ GDCB 5420F/ HORT 5420F/ NREM 5420F/ NUTRS 5420F/ VMPM 5420F/ VDPAM 5420F).
Credits: 1. Contact Hours: Lecture 0.5, Laboratory 1.
Repeatable.

Prereq: Graduate Standing or Permission of Instructor
Includes: metabolomics and the techniques involved in metabolite profiling. For non-chemistry majoring students who are seeking analytical aspects into their biological research projects. Offered on a satisfactory-fail basis only. (Typically Offered: Fall)

(Cross-listed with BMS 5420G/ EEOB 5420G/ FSHN 5420G/ GDCB 5420G/ HORT 5420G/ NREM 5420G/ NUTRS 5420G/ VMPM 5420G/ VDPAM 5420G).
Credits: 1. Contact Hours: Lecture 0.5, Laboratory 1.
Repeatable.

Prereq: Graduate Standing or Permission of Instructor
Sessions in basic molecular biology techniques and related procedures. Offered on a satisfactory-fail basis only. (Typically Offered: Spring)

(Dual-listed with BBMB 4450).
Credits: 2. Contact Hours: Lecture 2.

Prereq: (BBMB 5060 AND BBMB 5070) OR Graduate Classification
Molecular mechanisms of cellular signaling including receptor activation, desensitization and cross talk, signal transduction pathways, nuclear receptors, growth factor and extracellular matrix activators, protein kinases, caspase and transcription factor downstream signals, and lipids, gases and cyclic nucleotides as regulators of cell signaling. Course content includes current literature, student and instructor presentations and, for BBMB 5450 students only, research proposal writing and review. Offered even-numbered years. (Typically Offered: Spring)

(Cross-listed with CHEM 5490).
Credits: 3. Contact Hours: Lecture 3.

Prereq: Graduate Standing or Permission of Instructor
Theoretical principles of NMR, practical aspects of experimental NMR, solution and solid state NMR, methodologies for molecule characterization, protein structure determination, NMR relaxation, and recent advances. (Typically Offered: Spring)

Credits: 2. Contact Hours: Lecture 2.

Prereq: Graduate Standing or Permission of Instructor
Principles and applications of chemical and physical methods to analyze biological structures and function ranging from cells to individual biomolecules. Offered even-numbered years. (Typically Offered: Fall)

(Dual-listed with BBMB 4610).
Credits: 2. Contact Hours: Lecture 2.

Prereq: Graduate Standing or Permission of Instructor
Physical methods for the study of molecular structure and organization of biological materials. X-ray diffraction, nuclear magnetic resonance, hydrodynamics and fluorescence spectroscopy. Registration for the graduate credit commits the student to graduate-level examinations, which differ from undergraduate-level examinations in the number and/or difficulty of questions. (Typically Offered: Spring)

Credits: 2. Contact Hours: Lecture 1, Laboratory 3.

Prereq: Senior or Graduate classification or Permission of Instructor
Practice in methods of X-ray diffraction, nuclear magnetic resonance, hydrodynamics and fluorescence spectroscopy as applied to macromolecules. (Typically Offered: Spring)

(Cross-listed with BCB 5690/ COMS 5690/ CPRE 5690/ GDCB 5690).
Credits: 3. Contact Hours: Lecture 3.

Prereq: Graduate Standing or Permission of Instructor
Molecular structures including genes and gene products: protein, DNA and RNA structure. Structure determination methods, structural refinement, structure representation, comparison of structures, visualization, and modeling. Molecular and cellular structure from imaging. Analysis and prediction of protein secondary, tertiary, and higher order structure, disorder, protein-protein and protein-nucleic acid interactions, protein localization and function, bridging between molecular and cellular structures. Molecular evolution. (Typically Offered: Fall)

Credits: 1-30. Repeatable.

Prereq: Instructor Permission for Course
By arrangement.

Credits: 1. Repeatable.

Prereq: Graduate Standing or Permission of Instructor
Workshops in selected topics in biochemistry and biophysics. Credit in this course does not meet the requirement for advanced graduate electives in Biochemistry. Spring only: BBMB Undergraduate Research Symposium participation. Scheduled class meetings are required in addition to attending the symposium. (Typically Offered: Fall, Spring)

(Cross-listed with MICRO 6150/ VMPM 6150).
Credits: 3. Contact Hours: Lecture 3.

Current topics in molecular aspects of immunology: T and B cell receptors; major histocompatibility complex; antibody structure; immunosuppressive drugs and viruses; and intracellular signaling pathways leading to expression of genes that control and activate immune function. Offered odd-numbered years. (Typically Offered: Fall)

(Cross-listed with GDCB 6610/ KIN 6610/ NEURO 6610).
Credits: 3. Contact Hours: Lecture 3.
Repeatable.

Prereq: NEURO 5560 (or comparable course) or permission of instructor
Students will present three journal articles and two overview lectures on topics in neuroscience that are related but outside of their own research interest. Offered even-numbered years. (Typically Offered: Spring)

Credits: 2. Contact Hours: Lecture 2.

In-depth discussion of nucleic acid properties, structures and structure/function relationships. Interactions between nucleic acids and proteins will be emphasized. Offered even-numbered years. (Typically Offered: Fall)

Credits: 1. Contact Hours: Lecture 1.
Repeatable.

Student presentations. (Typically Offered: Fall, Spring)

Credits: Required. Contact Hours: Lecture 1.
Repeatable.

Faculty, staff and invited guest research seminar. (Typically Offered: Fall, Spring)

(Cross-listed with AGRON 6960/ PLBIO 6960/ FOR 6960/ GDCB 6960/ HORT 6960).
Credits: 1. Contact Hours: Lecture 1.
Repeatable.

Research seminars by faculty and graduate students. Offered on a satisfactory-fail basis only. (Typically Offered: Fall, Spring)

(Cross-listed with MCDB 6980/ GDCB 6980/ MICRO 6980/ VMPM 6980).
Credits: 1-2. Contact Hours: Lecture 2.
Repeatable.

Student and faculty presentations. (Typically Offered: Spring)

Credits: 1-30. Repeatable.

Prereq: Instructor Permission for Course
Research. (Typically Offered: Fall, Spring)