The department of Biochemistry, Biophysics & Molecular Biology offers majors in biochemistry or biophysics in the College of Liberal Arts and Sciences and a major in agricultural biochemistry in the College of Agriculture and Life Sciences.
Biochemists and biophysicists seek to understand life processes in terms of chemical and physical principles. They conduct research in the frontiers of biology such as metabolic networking; structure and function of enzymes, membranes, and hormones; computational approaches; genomic and proteomic technology; protein engineering; plant biotechnology; muscle structure and function; and the design and evaluation of drugs for the treatment of disease. Biochemistry, biophysics and molecular biology provide the basis for much of modern biotechnology. Graduates have opportunities in industry, especially the biotechnology sector, in universities, veterinary and medical schools, and government laboratories. Students who meet the necessary high scholastic standards have the opportunity to continue their education to pursue advanced degrees in graduate school, medicine, pharmacy or veterinary medicine.
Graduates of biochemistry, agricultural biochemistry and biophysics understand the chemical principles of biological systems including molecular biology. They have developed laboratory expertise in modern biochemical techniques, including the ability to analyze data and prepare scientific reports. Most have participated in undergraduate research and have developed the skills necessary for both written and oral presentations at a level that will serve the student both within the university and in postgraduate professional life. Graduates have the experience of interacting with persons of different disciplines and cultures. Students have the training in biological and physical science and mathematics to solve problems of broad scope in biological, biomedical and environmental sciences and to provide leadership in diverse scientific and technological arenas.
A program that combines a bachelor of science and masters of science in biochemistry or biophysics is offered.
Biochemistry or Biophysics Majors in the College of Liberal Arts and Sciences
For the undergraduate curriculum leading to the degree bachelor of science, see College of Agriculture, Agricultural biochemistry.
Biochemistry and biophysics are recommended to students whose career interests involve advanced graduate or medical study or employment in biochemistry or biophysics, or in related areas of the biological or medical sciences.
Biochemistry undergraduate major program of study
Total Degree Requirement: 120 cr.
BBMB 101 | Introduction to Biochemistry | 1 |
BBMB 102 | Introduction to Biochemistry Laboratory | 1 |
BBMB 201 | Chemical Principles in Biological Systems | 2 |
BBMB 404 | Biochemistry I | 3 |
or (4 credits) | ||
Amino Acids and Proteins | ||
Bioenergetics and Metabolism | ||
BBMB 405 | Biochemistry II | 3 |
or (4 credits) | ||
Membrane Biochemistry | ||
Biochemistry of Nucleic Acids | ||
BBMB 411 | Techniques in Biochemical Research | 4 |
BBMB 461 | Molecular Biophysics | 2 |
or BBMB 561 | Molecular Biophysics | |
BBMB 561L | Laboratory in Molecular Biophysics | 2-3 |
or CHEM 322L | Laboratory in Physical Chemistry | |
BBMB 490 | Independent Study (Not required) | 1-3 |
BBMB 499 | Undergraduate Research (Not required but strongly encouraged) | 1-5 |
Take one of the following: | 5-7 | |
Advanced General Chemistry | ||
General Chemistry I and General Chemistry II | ||
Take one of the following: | ||
Laboratory in Advanced General Chemistry | ||
or CHEM 177N | Laboratory in General Chemistry I | |
or CHEM 177L | Laboratory in General Chemistry I | |
CHEM 211 & 211L | Quantitative and Environmental Analysis and Quantitative and Environmental Analysis Laboratory | 4 |
CHEM 324 | Introductory Quantum Mechanics | 3 |
CHEM 325 | Chemical Thermodynamics | 3 |
CHEM 331 & CHEM 332 | Organic Chemistry I and Organic Chemistry II | 6 |
CHEM 333L | Laboratory in Organic Chemistry I (for Chemistry and Biochemistry Majors) | 1-2 |
or CHEM 331L | Laboratory in Organic Chemistry I | |
CHEM 334L | Laboratory in Organic Chemistry II (for Chemistry and Biochemistry Majors) | 1-2 |
or CHEM 332L | Laboratory in Organic Chemistry II | |
MATH 165 | Calculus I | 4 |
MATH 166 | Calculus II | 4 |
MATH 265 | Calculus III | 3-4 |
or MATH 266 | Elementary Differential Equations | |
or MATH 267 | Elementary Differential Equations and Laplace Transforms | |
PHYS 221 & PHYS 222 | Introduction to Classical Physics I and Introduction to Classical Physics II | 10 |
BIOL 211 & BIOL 212 | Principles of Biology I and Principles of Biology II | 6 |
BIOL 211L | Principles of Biology Laboratory I | 1 |
or BIOL 212L | Principles of Biology Laboratory II | |
or BIOL 313L | Genetics Laboratory | |
BIOL 313 | Principles of Genetics | 3 |
BIOL 314 | Principles of Molecular Cell Biology | 3 |
Biological Science electives from Biochemistry, Biology, Chemistry, Genetics, Microbiology | 4 | |
Total Credits | 81-93 |
Communication Proficiency: A grade of C or better is required in ENGL 250. For students fulfilling the upper-level requirement with BBMB 411, a grade of 80% or better must be earned on two journal-style written reports.
LIB 160 | Information Literacy | 1 |
ENGL 150 | Critical Thinking and Communication | 3 |
ENGL 250 | Written, Oral, Visual, and Electronic Composition | 3 |
One course from the following: | ||
BBMB 411 | Techniques in Biochemical Research | 4 |
ENGL 305 | Creative Writing: Nonfiction | 3 |
ENGL 309 | Proposal and Report Writing | 3 |
ENGL 314 | Technical Communication | 3 |
General Education Area
Arts and Humanities | 12 | |
Social Sciences | 9 | |
International Perspectives | 3 | |
U.S. Diversity | 3 |
Biophysics undergraduate major program of study
Total Degree Requirement: 120 cr,
BBMB 101 | Introduction to Biochemistry | 1 |
BBMB 102 | Introduction to Biochemistry Laboratory | 1 |
BBMB 201 | Chemical Principles in Biological Systems | 2 |
BBMB 404 | Biochemistry I | 3 |
or BBMB 420 | Mammalian Biochemistry | |
BBMB 411 | Techniques in Biochemical Research | 4 |
BBMB 461 | Molecular Biophysics | 2 |
or BBMB 561 | Molecular Biophysics | |
BBMB 561L | Laboratory in Molecular Biophysics | 2-3 |
or CHEM 322L | Laboratory in Physical Chemistry | |
Take one of the following: | 5-7 | |
Advanced General Chemistry | ||
General Chemistry I and General Chemistry II | ||
CHEM 201L | Laboratory in Advanced General Chemistry | 1 |
or CHEM 177N | Laboratory in General Chemistry I | |
or CHEM 177L | Laboratory in General Chemistry I | |
CHEM 211 & 211L | Quantitative and Environmental Analysis and Quantitative and Environmental Analysis Laboratory | 4 |
CHEM 324 | Introductory Quantum Mechanics | 3 |
CHEM 325 | Chemical Thermodynamics | 3 |
CHEM 331 & CHEM 332 | Organic Chemistry I and Organic Chemistry II | 6 |
MATH 165 | Calculus I | 4 |
MATH 166 | Calculus II | 4 |
MATH 265 | Calculus III | 4 |
MATH 266 | Elementary Differential Equations | 3 |
MATH 207 | Matrices and Linear Algebra | 3 |
or MATH 317 | Theory of Linear Algebra | |
PHYS 221 & PHYS 222 | Introduction to Classical Physics I and Introduction to Classical Physics II | 10 |
One course from the following: | ||
Numerical Methods for Differential Equations | ||
Methods of Multivariate Analysis | ||
Empirical Methods for the Computational Sciences | ||
COM S 207 | Fundamentals of Computer Programming | 3 |
STAT 305 | Engineering Statistics | 3-4 |
or STAT 231 | Probability and Statistical Inference for Engineers | |
BIOL 211 & BIOL 212 | Principles of Biology I and Principles of Biology II | 6 |
BIOL 211L | Principles of Biology Laboratory I | 1 |
or BIOL 212L | Principles of Biology Laboratory II | |
Additional 300+ or higher level courses in biochemistry, biophysics, biological sciences, chemistry or physics. | 7 | |
Total Credits | 85-89 |
Communication Proficiency: A grade of C or better is required in ENGL 250. For students fulfilling the upper-level requirement with BBMB 411, a grade of 80% or better must be earned on two journal-style written reports.
LIB 160 | Information Literacy | 1 |
ENGL 150 | Critical Thinking and Communication | 3 |
ENGL 250 | Written, Oral, Visual, and Electronic Composition | 3 |
One course from the following: | ||
BBMB 411 | Techniques in Biochemical Research | 4 |
ENGL 305 | Creative Writing: Nonfiction | 3 |
ENGL 309 | Proposal and Report Writing | 3 |
ENGL 314 | Technical Communication | 3 |
General Education Area
Arts and Humanities | 12 | |
Social Sciences | 9 | |
U.S. Diversity | 3 | |
International Perspectives | 3 |
Biochemistry minor is offered in both the College of Liberal Arts and Sciences and Agriculture and Life Sciences
BBMB 404 | Biochemistry I | 3 |
BBMB 405 | Biochemistry II | 3 |
BBMB 411 | Techniques in Biochemical Research | 4 |
One course from the following: | 2-3 | |
Molecular Biophysics (2 crs) | ||
Molecular Biophysics (2 crs) | ||
Chemical Thermodynamics | ||
300+ level courses in BBMB or CHEM to 15 cr total | 3-4 | |
Total Credits | 15-17 |
These lists of courses should not be regarded as statements of fixed requirements or as complete outlines of the work necessary for the major. They are given solely for the convenience of students or advisers who wish to estimate the amount of basic study that may be needed.
See also the B.S./M.S. program under Graduate Study.
Biochemistry, B.S.
Freshman | |||
---|---|---|---|
Fall | Credits | Spring | Credits |
BBMB 101 | 1 | BBMB 102 | 1 |
CHEM 201* | 5 | CHEM 211 | 2 |
CHEM 201L* | 1 | CHEM 211L | 2 |
MATH 165** | 4 | MATH 166 | 4 |
ENGL 150 | 3 | BIOL 211 | 3 |
LIB 1601 | 1 | BIOL 211L3 | 1 |
LAS General Education requirement2 | 3 | ||
15 | 16 | ||
Sophomore | |||
Fall | Credits | Spring | Credits |
CHEM 331 | 3 | BBMB 201 | 2 |
CHEM 331L or 333L | 1-2 | CHEM 332 | 3 |
MATH 265 or 266 | 3-4 | CHEM 332L or 334L | 1-2 |
BIOL 212 | 3 | PHYS 222 | 5 |
PHYS 221 | 5 | ENGL 2501 | 3 |
15-17 | 14-15 | ||
Junior | |||
Fall | Credits | Spring | Credits |
BBMB 4044 | 3 | BBMB 4054 | 3 |
BIOL 313 | 3 | BIOL 314 | 3 |
LAS General Education Requirement2 | 3 | LAS General Education Requirement2 | 3 |
LAS General Education Requirement2 | 3 | LAS General Education Requirement2 | 3 |
LAS World Language Requirement8 | 4 | LAS World Language Requirement8 | 4 |
16 | 16 | ||
Senior | |||
Fall | Credits | Spring | Credits |
BBMB 4111 | 4 | BBMB 461 | 2 |
CHEM 324 | 3 | Biological Science Elective6 | 4 |
LAS General Education Requirement2 | 3 | CHEM 325 | 3 |
LAS General Education Requirement2 | 3 | BBMB 561L7 | 2 |
BBMB 4995 | var | BBMB 4995 | var |
13 | 11 | ||
Total Credits: 116-119 |
* | General Chemistry I and II (177, 177N or 177L and 178) are acceptable substitutes for CHEM 201 and 201L. |
** | ALEKS assessment determines math placement. |
1 | Communication Proficiency: A grade of C or better is required in ENGL 250. For students fulfilling the upper-level requirement with BBMB 411, a grade of 80% or better must be earned on two journal-style written reports. |
2 | Liberal Arts and Sciences (LAS) General Education requirements include: 12cr. Arts and Humanities, 9 cr. Social Sciences and 11 cr. Natural Sciences (8 cr.) and Math (3 cr.). |
3 | One Biology laboratory course is required. Choose Biol 211L, 212L or 313L. |
4 | Students have the option of choosing the senior level biochemistry sequence for 6 credits (BBMB 404 and BBMB 405) or the graduate-level biochemistry sequence for 8 credits (BBMB 504, 505 and BBMB 506, 507). |
5 | Undergraduate study or research, BBMB 490 or 499, is recommended but not required. Credit value is variable. |
6 | Four credits of electives in Biological Sciences are required. |
7 | CHEM322L may be taken as a substitute for BBMB 561L. |
8 | World Language Requirement: (www.las.iastate.edu/academics/learning_goals.shtml) |
Biophysics, B.S.
Freshman | |||
---|---|---|---|
Fall | Credits | Spring | Credits |
BBMB 101 | 1 | BBMB 102 | 1 |
CHEM 201* | 5 | CHEM 211 | 2 |
or CHEM 177 and CHEM 178 | CHEM 211L | 2 | |
CHEM 201L or 177L* | 1 | MATH 166 | 4 |
MATH 165** | 4 | BIOL 211 | 3 |
ENGL 150 | 3 | BIOL 211L3 | 1 |
LIB 1601 | 1 | COM S 207 | 3 |
15 | 16 | ||
Sophomore | |||
Fall | Credits | Spring | Credits |
CHEM 331 | 3 | BBMB 201 | 2 |
MATH 265 | 4 | CHEM 332 | 3 |
BIOL 212 | 3 | MATH 266 | 3 |
PHYS 221 | 5 | PHYS 222 | 5 |
ENGL 2501 | 3 | ||
15 | 16 | ||
Junior | |||
Fall | Credits | Spring | Credits |
BBMB 4044 | 3 | CHEM 325 | 3 |
CHEM 324 | 3 | BBMB 461 | 2 |
LAS World Language Requirement8 | 4 | BBMB 561L7 | 2 |
Science Elective 6 | 3 | MATH 317 | 4 |
LAS General Education Requirement2 | 3 | ||
LAS World Language Requirement8 | 4 | ||
13 | 18 | ||
Senior | |||
Fall | Credits | Spring | Credits |
BBMB 4111 | 4 | Science Elective3 | |
Science Elective 300+5 | 3 | LAS General Educaton Requirement2 | 3 |
LAS General Education Requirement2 | 3 | LAS General Educaton Requirement2 | 3 |
STAT 231 or 305 | 4 | LAS General Education Requirement2 | 3 |
LAS General Education Requirement2 | 3 | BBMB 4995 | var |
BBMB 499 or 4905 | var | ||
17 | 9 | ||
Total Credits: 119 |
* | General Chemistry I and II (177, 177n or 177l and 178) are acceptable substitutes for CHEM 201 and 201L. |
** | ALEKS assessment determines math placement. |
1 | Communication Proficiency: A grade of C or better is required in ENGL 250. For students fulfilling the upper-level requirement with BBMB 411, a grade of 80% or better must be earned on two journal-style written reports. |
2 | Liberal Arts and Sciences (LAS) General Education Requirements include a minimum of: 12 cr. Arts and Humanities, 9 cr. Social Sciences and 11 cr Natural Sciences (8 cr.) and Math (3 cr.) Students in all ISU majors must complete a 3-cr. course in U.S. Diversity and a 3-cr. course in International Perspectives. Discuss with your adviser how the two courses you select can be applied to address general education requirements. Check for a list of approved courses at: http://www.registrar.iastate.edu/courses/div-ip-guide.html |
3 | One Biology laboratory course is required. Choose BIOL 211L or 212L. |
4 | Students have the option of choosing BBMB 405 or BBMB 420. |
5 | Undergraduate study or research, BBMB 490 or 499, is recommended but not required. Credit value is variable. |
6 | Seven additional science elective credits 300+; biochemistry, biophysics, biological sciences, chemistry or physics. |
7 | CHEM 322L can substitute for BBMB 561L. |
8 | World Language Requirement: (www.las.iastate.edu/academics/learning_goals.shtml) |
Graduate Study
The department offers work for the degrees master of science and doctor of philosophy with majors in biochemistry and biophysics and with interdepartmental majors in bioinformatics and computational biology, genetics and genomics, immunobiology, molecular, cellular, and developmental biology, neuroscience, plant biology, and toxicology. Minor work is offered to students taking major work in other departments.
Prerequisite to graduate work is a sound undergraduate background in biology, chemistry, mathematics, and physics.
All graduate students are required by the department to teach as part of their training for an advanced degree.
The department offers a B.S./M.S. program in biochemistry and biophysics that allows students to obtain both the B.S. and M.S. degrees in five years. The program is open to students in the College of Liberal Arts and Sciences and in the College of Agriculture and Life Sciences. Students interested in this program should contact the department office for details. Application for admission to the Graduate College should be made near the end of the junior undergraduate (third) year. Students would begin research for the M.S. thesis during the summer semester after their junior year and are eligible for research assistantships.
Courses
Courses primarily for undergraduates:
(1-0) Cr. 1. F.
Research activities, career opportunities in biochemistry and biophysics, and an introduction to the structure of biologically important compounds. For students majoring in biochemistry, agricultural biochemistry or biophysics or considering one of these majors.
(0-2) Cr. 1. S.
Prereq: Credit or enrollment in CHEM 177 and CHEM 177L or CHEM 201 and CHEM 201L
Topics in the scientific background of biochemistry, such as macromolecules, metabolism, and catalysis. Laboratory experimentation covers biochemical concepts and the study of bio-molecules including proteins, lipids and nucleic acids. A significant component is practice in scientific communication. For students majoring in biochemistry, agricultural biochemistry or biophysics or considering one of these majors.
(Cross-listed with FS HN). (2-0) Cr. 2. F.
An introduction to the major classes of biomolecules, basic biochemical concepts, enzymology, metabolism and genetic engineering as they apply to the production and flavor of beer. All aspects of the biochemistry of beer will be covered, including the malting of barley, starch conversion, yeast fermentation and the chemical changes that occur during the aging of beer. Intended for non-majors.
Natural science majors are limited to elective credit only.
(2-0) Cr. 2. S.
Prereq: Credit or enrollment in CHEM 332
Survey of chemical principles as they apply in biological systems including: water, organic chemistry of functional groups in biomolecules and biochemical cofactors, weak bonds and their contribution to biomolecular structure, oxidation-reduction reactions and redox potential, thermodynamic laws and bioenergetics, chemical equilibria and kinetics, inorganic chemistry in biological systems, data presentation. The subjects will be taught using molecules from biological systems as examples. Intended for majors in biochemistry, biophysics or agricultural biochemistry.
(3-0) Cr. 3. F.S.
Prereq: CHEM 163, CHEM 167, or CHEM 177
Fundamentals necessary for an understanding of biochemical processes. Primarily for students in agriculture.
Not acceptable for credit toward a major in biochemistry, biophysics, or agricultural biochemistry. Credit for both BBMB 221 and Chem 231 may not be applied toward graduation.
(3-0) Cr. 3. F.S.SS.
Prereq: CHEM 231 or CHEM 331
A survey of biochemistry: structure and function of amino acids, proteins, carbohydrates, lipids, and nucleic acids; enzymology; metabolism; biosynthesis; and selected topics.
Not acceptable for credit toward a major in biochemistry, biophysics, or agricultural biochemistry.
(3-0) Cr. 3. F.
Prereq: CHEM 231 or CHEM 331; BIOL 212; BIOL 313 and BIOL 314 strongly recommended.
Understanding biological systems at the molecular level; chemistry of biological macromolecules, enzyme function and regulation, metabolic pathways; integration of metabolism in diverse living systems. For students in biology and related majors who do not require the more rigorous treatment of biochemistry found in BBMB 404/405.
Not acceptable for credit toward a major in biochemistry, biophysics, or agricultural biochemistry.
(3-0) Cr. 3. F.
Prereq: CHEM 332
A general overview for graduate and advanced undergraduate students in agricultural, biological, chemical and nutritional sciences. Chemistry of amino acids, proteins, carbohydrates, and lipids, vitamins; protein structure; enzymology; carbohydrate metabolism.
Credit for both BBMB 420 and the BBMB 404 - 405 sequence may not be applied toward graduation.
(3-0) Cr. 3. S.
Prereq: BBMB 404
A general overview for graduate and advanced undergraduate students in agricultural, biological, chemical, and nutritional sciences. Metabolism of carbohydrates, amino acids, nucleotides and lipids; formation, turnover, and molecular relationships among DNA, RNA, and proteins; genetic code; regulation of gene expression; selected topics in the molecular physiology of plants and animals.
Credit for both BBMB 420 and the BBMB 404 - BBMB 405 sequence may not be applied toward graduation.
(2-8) Cr. 4. F.
Prereq: Credit or enrollment in BBMB 404 or BBMB 504 and BBMB 505; CHEM 211
Laboratory experimentation and techniques for studying biochemistry, including: chromatographic methods; electrophoresis; spectrophotometry; enzyme purification; enzyme kinetics; and characterization of carbohydrates, proteins, lipids, and nucleic acids. Scientific communication and technical writing are emphasized.
(3-0) Cr. 3. F.
Prereq: CHEM 332, BIOL 314
Structure and function of proteins; enzymology; biological oxidation; chemistry and metabolism of carbohydrates, lipids, amino acids and nucleic acids; protein synthesis and the genetic code; relationship of biochemistry to selected animal diseases. Biochemistry of higher animals emphasized.
Not acceptable for credit toward a major in agricultural biochemistry or biochemistry. Acceptable for credit toward a major in biophysics. Credit for both BBMB 420 and the BBMB 404 - 405 sequence may not be applied toward graduation.
(Dual-listed with BBMB 530). (Cross-listed with MICRO). (3-0) Cr. 3. Alt. S., offered odd-numbered years.
Prereq: MICRO 302, MICRO 302L
Survey of the diverse groups of procaryotes emphasizing important and distinguishing metabolic, phylogenetic, morphological, and ecological features of members of those groups.
(Cross-listed with MICRO). (2-6) Cr. 4. F.
Prereq: MICRO 302, MICRO 302L, CHEM 332, BIOL 313L
Fundamental techniques and theory for studying the cellular mechanisms, genetic processes and diversity of microbial life. Experimental techniques will include isolation and physiological characterization of bacteria that inhabit different environments as well as an emphasis on genetic and molecular techniques to understand antibiotic resistance processes and mechanisms. Also included are techniques for phylogenetic characterization, measuring gene expression, and genetic manipulation of bacteria. Essential components for the effective communication of scientific results are also emphasized.
(Dual-listed with BBMB 561). (2-0) Cr. 2. S.
Prereq: Credit or enrollment in MATH 166 and CHEM 178 and PHYS 222 or PHYS 112.
Physical methods for the study of molecular structure and organization of biological materials. X-ray diffraction, nuclear magnetic resonance, hydrodynamics and fluorescence spectroscopy. Registration for the graduate credit commits the student to graduate-level examinations, which differ from undergraduate-level examinations in the number and/or difficulty of questions.
Cr. 1-3. Repeatable. F.S.SS.
Prereq: College of Agriculture: junior or senior classification and permission of instructor; College of Liberal Arts and Sciences: permission of instructor.
Independent study with a faculty mentor.
No more than 9 credits of BBMB 490 may count toward graduation.
Cr. 1-3. Repeatable. F.S.SS.
Prereq: College of Agriculture: junior or senior classification and permission of instructor; College of Liberal Arts and Sciences: permission of instructor
Independent study with a faculty mentor.
No more than 9 credits of BBMB 490 may count toward graduation.
Cr. 1-5. Repeatable. F.S.SS.
Prereq: Permission of faculty member with whom student proposes to work.
Independent research under faculty guidance.
Courses primarily for graduate students, open to qualified undergraduates:
(2-0) Cr. 2. F.
Prereq: CHEM 332 or equivalent
Review of amino acids and proteins, including atomic interactions, thermodynamics, structure and properties of amino acids, post-translational modifications, protein expression, purification and analysis, protein secondary, tertiary and quaternary structure, protein folding, oxygen transport and hemoglobin, models for equilibrium binding, elementary reactions and enzyme kinetics, biosynthesis of amino acids: pathways and mechanisms.
(2-0) Cr. 2. F.
Prereq: CHEM 211, CHEM 332; a previous course in biochemistry is strongly recommended
Examination of catabolic pathways involved in the oxidation of organic and inorganic molecules, and energy metabolism involving inputs from light or other non-light sources. Central metabolism and glycolysis, fermentation, aerobic and anaerobic respiration, photosynthesis.
(2-0) Cr. 2.
Prereq: CHEM 332 or equivalent
Analysis of the structure, function, and synthesis of membranes. Bacterial and eukaryotic membrane characteristics. Membrane transport and signaling mechanisms. Analysis of the structure and function of lipids and membrane proteins.
(2-0) Cr. 2. S.
Prereq: CHEM 332 or equivalent
Analysis of the chemical structure, function, synthesis, and metabolism of nucleic acids. Chemical characterization of nucleotides, polynucleotides, DNA, and RNA. Analysis of transcription, translation, and the genetic code.
(2-0) Cr. 2. F.
Prereq: BIOL 313, BBMB 405, BBMB 502, BBMB 506 and 507 or GEN 409, or equivalent
Biochemical processes that define structure and function of nucleic acids. Emphasis on the molecular processes that take place during synthesis, processing, and function of different RNA species; review of recent advances in RNA research.
(Dual-listed with BBMB 430). (Cross-listed with MICRO). (3-0) Cr. 3. Alt. S., offered odd-numbered years.
Prereq: MICRO 302, MICRO 302L
Survey of the diverse groups of procaryotes emphasizing important and distinguishing metabolic, phylogenetic, morphological, and ecological features of members of those groups.
(Cross-listed with B M S, EEOB, FS HN, GDCB, HORT, NREM, NUTRS, V MPM, VDPAM). Cr. 1. Repeatable. F.S.
Includes genetic engineering procedures, sequencing, PCR, and genotyping.
Offered on a satisfactory-fail basis only.
(Cross-listed with B M S, EEOB, FS HN, GDCB, HORT, NREM, NUTRS, VDPAM). Cr. 1. Repeatable. S.SS.
Prereq: Graduate classification
Techniques. Includes: fermentation, protein isolation, protein purification, SDS-PAGE, Western blotting, NMR, confocal microscopy and laser microdissection, Immunophenotyping, and monoclonal antibody production. Sessions in basic molecular biology techniques and related procedures.
Offered on a satisfactory-fail basis only.
(Cross-listed with B M S, EEOB, FS HN, GDCB, HORT, NREM, NUTRS, V MPM, VDPAM). Cr. 1. Repeatable. F.S.
Includes: immunophenotyping, ELISA, flow cytometry, microscopic techniques, image analysis, confocal, multiphoton and laser capture microdissection.
Offered on a satisfactory-fail basis only.
(Cross-listed with B M S, EEOB, FS HN, GDCB, HORT, NREM, NUTRS, V MPM, VDPAM). Cr. 1. Repeatable. S.
Includes: Agrobacterium and particle gun-mediated transformation of tobacco, Arabidopsis, and maize, and analysis of tranformants.
Offered on a satisfactory-fail basis only.
(Cross-listed with B M S, EEOB, FS HN, GDCB, HORT, NREM, NUTRS, V MPM, VDPAM). Cr. 1. Repeatable. F.
Includes: two-dimensional electrophoresis, laser scanning, mass spectrometry, and database searching.
Offered on a satisfactory-fail basis only.
(Cross-listed with B M S, EEOB, FS HN, GDCB, HORT, NREM, NUTRS, V MPM, VDPAM). Cr. 1. Repeatable. F.
Includes: metabolomics and the techniques involved in metabolite profiling. For non-chemistry majoring students who are seeking analytical aspects into their biological research projects.
Offered on a satisfactory-fail basis only.
(Cross-listed with B M S, EEOB, FS HN, GDCB, HORT, NREM, NUTRS, V MPM, VDPAM). Cr. 1. Repeatable. S.
Offered on a satisfactory-fail basis only.
(2-0) Cr. 2. Alt. F., offered even-numbered years.
Prereq: CHEM 325 or permission of instructor
Advanced solution state Nuclear Magnetic Resonance spectroscopy as applied to biological systems. Topics include theoretical principles of NMR, practical aspects of experimental NMR, methodologies for protein structure determination, NMR relaxation, recent advances in NMR spectroscopy.
(Dual-listed with BBMB 461). (2-0) Cr. 2. S.
Prereq: Credit or enrollment in MATH 166 and CHEM 178 and PHYS 222 or PHYS 112.
Physical methods for the study of molecular structure and organization of biological materials. X-ray diffraction, nuclear magnetic resonance, hydrodynamics and fluorescence spectroscopy. Registration for the graduate credit commits the student to graduate-level examinations, which differ from undergraduate-level examinations in the number and/or difficulty of questions.
(Cross-listed with BCB, COM S, CPR E, GDCB). (3-0) Cr. 3. F.
Prereq: BCB 567, BBMB 316, GEN 409, STAT 430
Molecular structures including genes and gene products: protein, DNA and RNA structure. Structure determination methods, structural refinement, structure representation, comparison of structures, visualization, and modeling. Molecular and cellular structure from imaging. Analysis and prediction of protein secondary, tertiary, and higher order structure, disorder, protein-protein and protein-nucleic acid interactions, protein localization and function, bridging between molecular and cellular structures. Molecular evolution.
Cr. arr.
By arrangement.
Cr. 1. Repeatable. F.S.
Prereq: Permission and signature of course administrator required.
Workshops in selected topics in biochemistry and biophysics. Credit in this course does not meet the requirement for advanced graduate electives in Biochemistry. Spring only: BBMB Undergraduate Research Symposium participation. Scheduled class meetings are required in addition to attending the symposium.
Courses for graduate students:
(Cross-listed with MICRO, V MPM). (3-0) Cr. 3. Alt. F., offered odd-numbered years.
Prereq: BBMB 405 or BBMB 506 and BBMB 507
Current topics in molecular aspects of immunology: T and B cell receptors; major histocompatibility complex; antibody structure; immunosuppressive drugs and viruses; and intracellular signaling pathways leading to expression of genes that control and activate immune function.
(2-0) Cr. 2. Alt. F., offered even-numbered years.
Prereq: BBMB 504 and BBMB 505
Fundamental and advanced enzyme kinetics. Topics include integrated rate equations, methods for deriving initial-rate equations, inhibition, product effects, methods for verifying kinetic mechanisms, allostery, hysteresis, isotope effects, and complex kinetic mechanisms.
(2-0) Cr. 2. Alt. S., offered odd-numbered years.
Prereq: BBMB 405 or BBMB 420; or BBMB 506 and BBMB 507
Molecular mechanisms of cellular signaling including receptor activation, desensitization and cross talk, signal transduction pathways, and nuclear receptors. Discussion includes a variety of cell surface receptors and their hormone; growth factor and extracellular matrix activators; protein kinases; caspase and transcription factor downstream signals; lipids, gases and cyclic nucleotides as regulators of cell signaling. Course content includes current literature, student and instructor presentations and research proposal writing.
(2-0) Cr. 2. Alt. F., offered even-numbered years.
Prereq: BBMB 405 or BBMB 506 and BBMB 507
Protein and lipid constituents of biological membranes. Structure and topography of membrane proteins. Selected topics concerning the membrane proteins involved in diverse biochemical processes, such as energy transduction transport across membranes, neurotransmission and signal transduction.
(Cross-listed with GDCB, NEURO). (2-0) Cr. 2-3. Repeatable. Alt. S., offered even-numbered years.
Prereq: NEURO 556 (or comparable course) or permission of instructor
Topics may include molecular and cellular neuroscience, neurodevelopment, neuroplasticity, neurodegenerative diseases, cognitive neuroscience, sensory biology, neural integration, membrane biophysics, neuroethology, techniques in neurobiology and behavior.
(Cross-listed with MCDB). (2-0) Cr. 2. Alt. S., offered even-numbered years.
Prereq: BBMB 404 and BBMB 504; and BBMB 506 and BBMB 507; or BBMB 405 or BBMB 505 and or GDCB 511
Analysis of the biochemical processes involved in expression of eucaryotic genes and the regulation thereof, including RNA polymerase, transcriptional regulatory proteins, enhancers and silencers, chromosome structure, termination, RNA processing, RNA transport, RNA turnover, small RNAs, translational regulation, protein turnover.
Cr. 1. Repeatable. F.S.
Prereq: Permission of instructor
Student presentations.
Cr. R. F.S.
Prereq: Permission of instructor
Faculty, staff and invited guest research seminar.
(Cross-listed with AGRON, FOR, GDCB, HORT, PLBIO). Cr. 1. Repeatable.
Research seminars by faculty and graduate students.
Offered on a satisfactory-fail basis only.
(Cross-listed with GDCB, MCDB, MICRO, V MPM). (2-0) Cr. 1-2. Repeatable. F.S.
Student and faculty presentations.
Cr. arr. Repeatable. F.S.
Prereq: Permission of instructor