Bioengineering (BIOE)

BIOE 220. Introduction to Biomedical Engineering.

(Cross-listed with CH E). (3-0) Cr. 3. S. Prereq: BIOL 212, ENGR 160 or equiv, MATH 166, CHEM 167 or CHEM 178, PHYS 222
Engineering analysis of basic biology and engineering problems associated with living systems and health care delivery. The course will illustrate biomedical engineering applications in such areas as: biotechnology, biomechanics, biomaterials and tissue engineering, and biosignal and image processing, and will introduce the basic life sciences and engineering concepts associated with these topics.

BIOE 325. Systems Biology for Engineering.

(Cross-listed with E E). (3-0) Cr. 3. Prereq: BIOE 210, MATH 267
Review of systems approaches for modeling. Introduction or review of methods for gene regulation in cells and how to model them. Auto regulation of gene networks. Feedforward modeling, timing considerations. Feedback mechanisms. Kinetic and rate-limiting steps.

BIOE 341. BioMEMs and Nanotechnology.

(3-0) Cr. 3. Prereq: BIOE 220
Overview of Micro-Electro-Mechanical-System (MEMS) technologies for bioengineering, fundamentals of microfluidic device design, fabrication, and characterization, survey of microfluidic functional building blocks for lab-on-a-chip applications including mixers, valves, channels, and chambers. Topics of nanotechnology in bioengineering, nanoscale building block technologies for bioengineering including self-assembling, surface chemical treatment, nano-imprinting, nano-particles, nano-tubes, nano-wires, and stimuli-responsive biomaterials.

BIOE 341L. BioMEMS and Nanotechnology Laboratory.

(0-3) Cr. 1. Prereq: BIOE 220, concurrent enrollment in BIOE 341
Introductory laboratory course accompanying BIOE 341. Design, fabrication, and characterization of BioMEMS lab-on-a-chip devices and nanoscale techniques for bioengineering. Student group projects. BioE341L not a necessary corequisite with BioE341.

BIOE 352. Molecular, Cellular and Tissue Biomechanics.

(3-0) Cr. 3. Prereq: BIOE 220, E M 324, MAT E 273
Introduction to the anatomy of the musculoskeletal system and connective tissue. Range of movement, joint dislocation, bone deformity and fracture. Application of continuum mechanics to both living and non-living systems. Laws of motion, free-body diagrams and simple force analysis of musculoskeletal system. Biomechanical response of soft and hard tissues with emphasis on microstructure and mechanical properties. Applications to bioengineering design.

BIOE 411. Bioprocessing and Bioproducts.

(3-0) Cr. 3. F. Prereq: A E 216 or equivalent, MATH 160 or MATH 165, one of CHEM 167 or higher, BIOL 173 or BIOL 211 or higher or BRT 501, senior or graduate classification
Sustainability, cleaner production. Taxonomy, kinetics, metabolism, aerobic and anaerobic fermentation. Biofuels, bioenergy and coproducts. Mass/energy balances, process integration, pretreatment, separation. Membrane reactors, bioelectrolysis, microbial fuel cells, nanotechnology, genetic engineering, mutagenesis.

BIOE 428. Image Processing with Biomedical Applications.

(3-0) Cr. 3. Prereq: E E 324
Review of signal processing, linear algebra, probability. Image sampling and quantization. Image transforms, image enhancement, image denoising/restoration. Tomographic reconstruction, segmentation and registration, recognition and shape analysis and applications in Computer Aided disease Detection (CAD).

BIOE 440. Biomedical Applications of Chemical Engineering.

(Cross-listed with CH E). (3-0) Cr. 3. Alt. F., offered odd-numbered years. Prereq: CH E 210, MATH 266, PHYS 222
Applications of material and energy balances, transport phenomena, chemical reaction engineering, and thermodynamics to problems in biomedical engineering and applied physiology; survey of biomedical engineering; biomaterials; biomedical imaging.

BIOE 450. Biosensing.

(3-0) Cr. 3. Prereq: BIOE 220
Overview of biosensors and bioanalytical challenges; designing for performance including various analytical problems, ion-selective membranes, characteristics of enzymes and basics of bioaffinity sensing; fundamentals of bioselective layers including depositing films and membranes, surfaces for immobilization and bioselective agents; survey of different biosensing technologies including electroanalytical, biomembrane, optical, and acoustic-wave based sensors.

BIOE 450L. Biosensing Laboratory.

(0-3) Cr. 1. Prereq: BIOE 220, concurrent enrollment in BIOE 450
Laboratory course accompanying BIOE 450. Design, fabrication, and characterization of various electrical, chemical, polymer, optical and acoustic sensors. Lab is not a necessary corequisite with BIOE 450.

BIOE 456. Biomaterials.

(Cross-listed with MAT E). (3-0) Cr. 3. F. Prereq: MAT E 216 or MAT E 273 or MAT E 392
Presentation of the basic chemical and physical properties of biomaterials, including metals, ceramics, and polymers, as they are related to their manipulation by the engineer for incorporation into living systems. Role of microstructure properties in the choice of biomaterials and design of artificial organs, implants, and prostheses.

BIOE 490. Independent Study.

Cr. 1-6. Repeatable, maximum of 6 credits. F.S.SS. Prereq: permission of chair for the bioengineering minor
Investigation of biomedical engineering topics of special interest to student and supervising faculty member with a final written report.